KCNS1

Protein-coding gene in the species Homo sapiens

KCNS1

Identifiers

Aliases

KCNS1, KV9.1, potassium voltage-gated channel modifier subfamily S member 1

External IDs

OMIM: 602905; MGI: 1197019; HomoloGene: 20517; GeneCards: KCNS1; OMA:KCNS1 - orthologs

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q13.12	Start	45,091,214 bp^[1]
Band	20q13.12	End	45,101,127 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 H3	Start	164,005,539 bp^[2]
Band	2\|2 H3	End	164,013,033 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

middle temporal gyrus

Brodmann area 23

cardia

Brodmann area 46

superior frontal gyrus

postcentral gyrus

orbitofrontal cortex

spinal ganglia

ventral tegmental area

superior vestibular nucleus

Top expressed in

parotid gland

superior frontal gyrus

calvaria

entorhinal cortex

primary motor cortex

hippocampus proper

esophagus

quadriceps femoris muscle

striated muscle tissue

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated potassium channel activity ion channel activity potassium channel regulator activity potassium channel activity protein binding delayed rectifier potassium channel activity voltage-gated ion channel activity
Cellular component	integral component of membrane membrane voltage-gated potassium channel complex plasma membrane perinuclear region of cytoplasm
Biological process	regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport regulation of delayed rectifier potassium channel activity potassium ion transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3787


16538

Ensembl


ENSG00000124134


ENSMUSG00000040164

UniProt


Q96KK3


O35173

RefSeq (mRNA)


NM_002251 NM_001322799


NM_008435

RefSeq (protein)


NP_001309728 NP_002242


NP_032461

Location (UCSC)

Chr 20: 45.09 – 45.1 Mb

Chr 2: 164.01 – 164.01 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily S member 1 is a protein that in humans is encoded by the KCNS1 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124134 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040164 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M (Oct 1997). "New modulatory alpha subunits for mammalian Shab K+ channels". J Biol Chem. 272 (39): 24371–9. doi:10.1074/jbc.272.39.24371. PMID 9305895.
^ ^a ^b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

External links

Kv9.1+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNS1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin