CLCC1

Protein-coding gene in the species Homo sapiens

CLCC1

Identifiers

Aliases

CLCC1, MCLC, chloride channel CLIC like 1

External IDs

OMIM: 617539; MGI: 2385186; HomoloGene: 9032; GeneCards: CLCC1; OMA:CLCC1 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p13.3	Start	108,929,508 bp^[1]
Band	1p13.3	End	108,963,457 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F3	Start	108,561,229 bp^[2]
Band	3\|3 F3	End	108,586,156 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

internal globus pallidus

stromal cell of endometrium

body of pancreas

islet of Langerhans

gastrocnemius muscle

corpus callosum

parotid gland

biceps brachii

endothelial cell

Top expressed in

spermatocyte

seminal vesicula

intercostal muscle

parotid gland

median eminence

proximal tubule

Paneth cell

submandibular gland

lacrimal gland

fossa

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	chloride channel activity
Cellular component	integral component of membrane Golgi apparatus endoplasmic reticulum membrane nucleus chloride channel complex intracellular membrane-bounded organelle
Biological process	chloride transport chloride transmembrane transport ion transport transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23155


229725

Ensembl


ENSG00000121940


ENSMUSG00000027884

UniProt


Q96S66


Q99LI2

RefSeq (mRNA)


NM_015127 NM_001048210 NM_001278202 NM_001278203


NM_001177770 NM_001177771 NM_145543 NM_001355632

RefSeq (protein)

NP_001041675 NP_001265131 NP_001265132 NP_055942 NP_001364387
NP_001364388 NP_001364389 NP_001364390 NP_001364391 NP_001364392 NP_001364393 NP_001364394 NP_001364395 NP_001364396 NP_001364397 NP_001364398 NP_001364399


NP_001171241 NP_001171242 NP_663518 NP_001342561

Location (UCSC)

Chr 1: 108.93 – 108.96 Mb

Chr 3: 108.56 – 108.59 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.^[5]^[6]

The protein encoded by this gene is a chloride channel which is related in sequence to the S. cerevisiae MID-1 stretch-activated channel. CLCC1 is located in the membranes of intracellular compartments including endoplasmic reticulum and the Golgi apparatus. It is highly expressed in the testis and moderately in the spleen, liver, kidney, heart, brain, and lung.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121940 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027884 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
^ ^a ^b Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I (June 2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus". J. Biol. Chem. 276 (23): 20413–8. doi:10.1074/jbc.M100366200. PMID 11279057.

External links

CLCC1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CLCC1 genome location and CLCC1 gene details page in the UCSC Genome Browser.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin