KCNK12

Protein-coding gene in the species Homo sapiens
KCNK12
Identifiers
AliasesKCNK12, K2p12.1, THIK-2, THIK2, potassium two pore domain channel subfamily K member 12
External IDsOMIM: 607366; MGI: 2684043; HomoloGene: 11107; GeneCards: KCNK12; OMA:KCNK12 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for KCNK12
Genomic location for KCNK12
Band2p16.3Start47,509,290 bp[1]
End47,570,985 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for KCNK12
Genomic location for KCNK12
Band17|17 E4Start88,053,229 bp[2]
End88,105,422 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • olfactory bulb

  • trigeminal ganglion

  • spinal ganglia

  • inferior olivary nucleus

  • cerebellum

  • cerebellar cortex

  • cerebellar hemisphere

  • sural nerve

  • entorhinal cortex

  • middle temporal gyrus
Top expressed in
  • cerebellar cortex

  • superior frontal gyrus

  • anterior horn of spinal cord

  • olfactory bulb

  • hippocampus proper

  • yolk sac

  • neural tube

  • bone marrow

  • mesencephalon

  • islet of Langerhans
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • potassium channel activity
  • voltage-gated ion channel activity
  • potassium ion leak channel activity
Cellular component
  • integral component of membrane
  • membrane
  • integral component of plasma membrane
Biological process
  • potassium ion transport
  • regulation of ion transmembrane transport
  • ion transport
  • stabilization of membrane potential
  • potassium ion transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56660

210741

Ensembl

ENSG00000184261

ENSMUSG00000050138

UniProt

Q9HB15

Q76M80

RefSeq (mRNA)

NM_022055

NM_199251

RefSeq (protein)

NP_071338

NP_954859

Location (UCSC)Chr 2: 47.51 – 47.57 MbChr 17: 88.05 – 88.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K2P12.1, is a potassium channel containing two pore-forming P domains.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184261 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050138 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302–11. doi:10.1074/jbc.M008985200. PMID 11060316.

Further reading

  • Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F (2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem. Biophys. Res. Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
  • Nyholt DR, LaForge KS, Kallela M, Alakurtti K, Anttila V, Farkkila M, Hamalainen E, Kaprio J, Kaunisto MA (2008). "A high-density association screen of 155 ion transport genes for involvement with common migraine". Hum. Mol. Genet. 17 (21): 3318–31. doi:10.1093/hmg/ddn227. PMC 2566523. PMID 18676988.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
  • Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Theilig F, Goranova I, Hirsch JR, Wieske M, ÜNsal S, Bachmann S, Veh RW, Derst C (2008). "Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney". Cell. Physiol. Biochem. 21 (1–3): 63–74. doi:10.1159/000113748. PMID 18209473. S2CID 26356698.

External links

  • v
  • t
  • e
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl−: Chloride channel
H+: Proton channel
M+: CNG cation channel
M+: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


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