KCNC4

Protein-coding gene in the species Homo sapiens

KCNC4

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1B4G, 1B4I, 1ZTN

Identifiers

Aliases

KCNC4, C1orf30, HKSHIIIC, KSHIIIC, KV3.4, potassium voltage-gated channel subfamily C member 4

External IDs

OMIM: 176265; MGI: 96670; HomoloGene: 68427; GeneCards: KCNC4; OMA:KCNC4 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p13.3	Start	110,210,314 bp^[1]
Band	1p13.3	End	110,283,100 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3 F2.3\|3 46.83 cM	Start	107,345,619 bp^[2]
Band	3 F2.3\|3 46.83 cM	End	107,366,868 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cingulate gyrus

prefrontal cortex

amygdala

dorsolateral prefrontal cortex

Brodmann area 9

hypothalamus

oocyte

hippocampus proper

thoracic aorta

ascending aorta

Top expressed in

olfactory epithelium

motor neuron

vastus lateralis muscle

facial motor nucleus

triceps brachii muscle

tibialis anterior muscle

skeletal muscle tissue

masseter muscle

supraoptic nucleus

substantia nigra

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	ion channel activity potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity protein binding
Cellular component	plasma membrane neuromuscular junction axon terminus voltage-gated potassium channel complex membrane integral component of membrane axon dendrite membrane neuronal cell body membrane neuronal cell body
Biological process	chemical synaptic transmission regulation of ion transmembrane transport regulation of neurotransmitter secretion protein homooligomerization potassium ion transmembrane transport potassium ion transport ion transport transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3749


99738

Ensembl


ENSG00000116396


ENSMUSG00000027895

UniProt


Q03721


Q8R1C0

RefSeq (mRNA)


NM_001039574 NM_004978 NM_153763 NM_001377330 NM_001377331


NM_145922 NM_001356447

RefSeq (protein)


NP_001034663 NP_004969 NP_001364259 NP_001364260


NP_666034 NP_001343376

Location (UCSC)

Chr 1: 110.21 – 110.28 Mb

Chr 3: 107.35 – 107.37 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), also known as K_v3.4, is a human gene.^[5]

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Several transcript variants encoding different isoforms have been found for this gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116396 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027895 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: KCNC4 potassium voltage-gated channel, Shaw-related subfamily, member 4".

Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
Vega-Saenz de Miera E, Moreno H, Fruhling D, et al. (1992). "Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel". Proc. Biol. Sci. 248 (1321): 9–18. Bibcode:1992RSPSB.248....9V. doi:10.1098/rspb.1992.0036. PMID 1381835. S2CID 8968480.
Ghanshani S, Pak M, McPherson JD, et al. (1992). "Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1". Genomics. 12 (2): 190–6. doi:10.1016/0888-7543(92)90365-Y. PMID 1740329.
Rudy B, Sen K, Vega-Saenz de Miera E, et al. (1991). "Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21". J. Neurosci. Res. 29 (3): 401–12. doi:10.1002/jnr.490290316. PMID 1920536. S2CID 27662306.
Covarrubias M, Wei A, Salkoff L, Vyas TB (1995). "Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate". Neuron. 13 (6): 1403–12. doi:10.1016/0896-6273(94)90425-1. PMC 2211371. PMID 7993631.
Beck EJ, Sorensen RG, Slater SJ, Covarrubias M (1998). "Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action". J. Gen. Physiol. 112 (1): 71–84. doi:10.1085/jgp.112.1.71. PMC 2229409. PMID 9649584.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Angulo E, Noé V, Casadó V, et al. (2005). "Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease". J. Neurochem. 91 (3): 547–57. doi:10.1111/j.1471-4159.2004.02771.x. PMID 15485486.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Abbott GW, Butler MH, Goldstein SA (2006). "Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis" (PDF). FASEB J. 20 (2): 293–301. doi:10.1096/fj.05-5070com. PMID 16449802. S2CID 21538479.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

PDB gallery

1b4g: CONTROL OF K+ CHANNEL GATING BY PROTEIN PHOSPHORYLATION: STRUCTURAL SWITCHES OF THE INACTIVATION GATE, NMR, 22 STRUCTURES
1b4i: CONTROL OF K+ CHANNEL GATING BY PROTEIN PHOSPHORYLATION: STRUCTURAL SWITCHES OF THE INACTIVATION GATE, NMR, 22 STRUCTURES
1ztn: INACTIVATION GATE OF POTASSIUM CHANNEL RAW3, NMR, 8 STRUCTURES

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin