KCNK13

Protein-coding gene in the species Homo sapiens
KCNK13
Identifiers
AliasesKCNK13, K2p13.1, THIK-1, THIK1, potassium two pore domain channel subfamily K member 13
External IDsOMIM: 607367; MGI: 2384976; HomoloGene: 69351; GeneCards: KCNK13; OMA:KCNK13 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for KCNK13
Genomic location for KCNK13
Band14q32.11Start90,061,994 bp[1]
End90,185,853 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for KCNK13
Genomic location for KCNK13
Band12|12 EStart99,930,758 bp[2]
End100,028,941 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • appendix

  • kidney

  • left lobe of thyroid gland

  • prefrontal cortex

  • right lobe of thyroid gland

  • hypothalamus

  • endometrium

  • Brodmann area 9

  • blood
Top expressed in
  • secondary oocyte

  • left lung lobe

  • superior frontal gyrus

  • globus pallidus

  • lateral geniculate nucleus

  • lateral hypothalamus

  • spinal cord

  • medial geniculate nucleus

  • suprachiasmatic nucleus

  • pontine nuclei
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • potassium channel activity
  • voltage-gated ion channel activity
  • potassium ion leak channel activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
Biological process
  • potassium ion transport
  • regulation of ion transmembrane transport
  • ion transport
  • stabilization of membrane potential
  • potassium ion transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56659

217826

Ensembl

ENSG00000152315

ENSMUSG00000045404

UniProt

Q9HB14

Q8R1P5

RefSeq (mRNA)

NM_022054

NM_001164426
NM_001164427
NM_146037

RefSeq (protein)

NP_071337

NP_001157898
NP_001157899
NP_666149

Location (UCSC)Chr 14: 90.06 – 90.19 MbChr 12: 99.93 – 100.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel, subfamily K, member 13, also known as KCNK13 is a human gene. The protein encoded by this gene, K2P13.1 is a potassium channel containing two pore-forming P domains.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152315 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045404 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302–11. doi:10.1074/jbc.M008985200. PMID 11060316.
  6. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Fearon IM, Campanucci VA, Brown ST, Hudasek K, o'Kelly IM, Nurse CA (2006). "Acute Hypoxic Regulation of Recombinant THIK-1 Stably Expressed in HEK293 Cells". The Arterial Chemoreceptors. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. Vol. 580. pp. 203–8, discussion 351–9. doi:10.1007/0-387-31311-7_31. ISBN 978-0-387-31310-8. PMID 16683720.
  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
  • Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Theilig F, Goranova I, Hirsch JR, Wieske M, ÜNsal S, Bachmann S, Veh RW, Derst C (2008). "Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney". Cell. Physiol. Biochem. 21 (1–3): 63–74. doi:10.1159/000113748. PMID 18209473.
  • Gierten J, Ficker E, Bloehs R, Schlömer K, Kathöfer S, Scholz E, Zitron E, Kiesecker C, Bauer A (2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". Br. J. Pharmacol. 154 (8): 1680–90. doi:10.1038/bjp.2008.213. PMC 2518462. PMID 18516069.

External links

  • v
  • t
  • e
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl−: Chloride channel
H+: Proton channel
M+: CNG cation channel
M+: TRP cation channel
H2O (+ solutes): Porin
Cytoplasm: Gap junction
By gating mechanism
Ion channel class
see also disorders


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