CLCN6

Protein-coding gene in the species Homo sapiens

CLCN6

Identifiers

Aliases

CLCN6, CLC-6, chloride voltage-gated channel 6, CONRIBA

External IDs

OMIM: 602726; MGI: 1347049; HomoloGene: 985; GeneCards: CLCN6; OMA:CLCN6 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p36.22	Start	11,806,096 bp^[1]
Band	1p36.22	End	11,848,079 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 E1\|4 78.67 cM	Start	148,088,716 bp^[2]
Band	4 E1\|4 78.67 cM	End	148,123,278 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

anterior pituitary

sural nerve

middle temporal gyrus

prefrontal cortex

cingulate gyrus

frontal pole

hypothalamus

Brodmann area 9

Brodmann area 10

right uterine tube

Top expressed in

substantia nigra

retinal pigment epithelium

supraoptic nucleus

medial vestibular nucleus

superior frontal gyrus

anterior horn of spinal cord

dorsal tegmental nucleus

ventral tegmental area

cerebellar cortex

dorsomedial hypothalamic nucleus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleotide binding ion channel activity ATP binding antiporter activity voltage-gated chloride channel activity protein binding chloride transmembrane transporter activity transmembrane transporter activity
Cellular component	integral component of membrane lysosomal membrane endosome endosome membrane membrane intracellular membrane-bounded organelle
Biological process	cell volume homeostasis response to mechanical stimulus chloride transport ion transmembrane transport ion transport signal transduction regulation of anion transmembrane transport transmembrane transport chloride transmembrane transport transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1185


26372

Ensembl


ENSG00000011021


ENSMUSG00000029016

UniProt


P51797


O35454

RefSeq (mRNA)


NM_001256959 NM_001286 NM_021735 NM_021736 NM_021737


NM_011929

RefSeq (protein)


NP_001243888 NP_001277


NP_036059

Location (UCSC)

Chr 1: 11.81 – 11.85 Mb

Chr 4: 148.09 – 148.12 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene.^[5]^[6]

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011021 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029016 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brandt S, Jentsch TJ (Feb 1996). "ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family". FEBS Lett. 377 (1): 15–20. doi:10.1016/0014-5793(95)01298-2. PMID 8543009. S2CID 717696.
^ ^a ^b "Entrez Gene: CLCN6 chloride channel 6".

External links

CLCN6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CLCN6 genome location and CLCN6 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin