Cyclic nucleotide-gated channel alpha 4

Protein-coding gene in the species Homo sapiens

CNGA4

Identifiers

Aliases

CNGA4, CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb, Cyclic nucleotide-gated channel alpha 4, cyclic nucleotide gated channel alpha 4, cyclic nucleotide gated channel subunit alpha 4

External IDs

OMIM: 609472 MGI: 2664099 HomoloGene: 13579 GeneCards: CNGA4

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11p15.4	Start	6,234,765 bp^[1]
Band	11p15.4	End	6,244,479 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 E3	Start	105,053,775 bp^[2]
Band	7\|7 E3	End	105,057,949 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

bronchial epithelial cell

right lung

caudate nucleus

prefrontal cortex

amygdala

Brodmann area 9

hypothalamus

left uterine tube

nucleus accumbens

Top expressed in

olfactory epithelium

secondary oocyte

spermatid

superior frontal gyrus

testicle

facial motor nucleus

extraocular muscle

olfactory bulb

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleotide binding cAMP binding voltage-gated potassium channel activity ion channel activity intracellular cAMP-activated cation channel activity intracellular cGMP-activated cation channel activity cGMP binding
Cellular component	Golgi-associated vesicle membrane integral component of membrane Golgi membrane membrane ciliary membrane integral component of plasma membrane
Biological process	transmembrane transport response to stimulus sensory perception of smell ion transport ion transmembrane transport regulation of membrane potential potassium ion transmembrane transport cation transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1262


233649

Ensembl


ENSG00000132259


ENSMUSG00000030897

UniProt


Q8IV77


Q3UW12

RefSeq (mRNA)


NM_001037329


NM_001033317

RefSeq (protein)


NP_001032406


NP_001028489

Location (UCSC)

Chr 11: 6.23 – 6.24 Mb

Chr 7: 105.05 – 105.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cyclic nucleotide-gated cation channel alpha-4 is a protein that in humans is encoded by the CNGA4 gene.^[5]^[6]^[7]

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132259 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030897 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bradley J, Frings S, Yau KW, Reed R (Dec 2001). "Nomenclature for Ion channel Subunits". Science. 294 (5549): 2095–6. doi:10.1126/science.294.5549.2095. PMC 2901924. PMID 11764791.
^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
^ ^a ^b "Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4".

External links

CNGA4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin