Mitochondrial ribosomal protein L23

Protein-coding gene in the species Homo sapiens
MRPL23
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J7Y, 3J9M

Identifiers
AliasesMRPL23, L23MRP, RPL23, RPL23L, mitochondrial ribosomal protein L23
External IDsOMIM: 600789; MGI: 1196612; HomoloGene: 7922; GeneCards: MRPL23; OMA:MRPL23 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for MRPL23
Genomic location for MRPL23
Band11p15.5Start1,947,278 bp[1]
End1,984,522 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for MRPL23
Genomic location for MRPL23
Band7 F5|7 87.95 cMStart142,086,423 bp[2]
End142,094,484 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • olfactory zone of nasal mucosa

  • apex of heart

  • right uterine tube

  • mucosa of transverse colon

  • anterior pituitary

  • left adrenal cortex

  • gastrocnemius muscle

  • skin of abdomen

  • minor salivary glands

  • right lobe of liver
Top expressed in
  • yolk sac

  • epiblast

  • embryo

  • quadriceps femoris muscle

  • blastocyst

  • embryo

  • neural tube

  • muscle tissue

  • morula

  • stomach
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • RNA binding
  • structural constituent of ribosome
Cellular component
  • mitochondrial inner membrane
  • ribosome
  • intracellular anatomical structure
  • mitochondrion
  • fibrillar center
  • mitochondrial large ribosomal subunit
Biological process
  • mitochondrial translational elongation
  • mitochondrial translational termination
  • protein biosynthesis
  • mitochondrial translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6150

19935

Ensembl

ENSG00000214026
ENSG00000288141

ENSMUSG00000037772

UniProt

Q16540

O35972

RefSeq (mRNA)

NM_021134

NM_011288

RefSeq (protein)

NP_066957

NP_035418

Location (UCSC)Chr 11: 1.95 – 1.98 MbChr 7: 142.09 – 142.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L23, mitochondrial is a protein that in humans is encoded by the MRPL23 gene.[5][6]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11.[6]

References

  1. ^ a b c ENSG00000288141 GRCh38: Ensembl release 89: ENSG00000214026, ENSG00000288141 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037772 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsang P, Gilles F, Yuan L, Kuo YH, Lupu F, Samara G, Moosikasuwan J, Goye A, Zelenetz AD, Selleri L (Feb 1996). "A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues". Hum Mol Genet. 4 (9): 1499–507. doi:10.1093/hmg/4.9.1499. PMID 8541832.
  6. ^ a b "Entrez Gene: MRPL23 mitochondrial ribosomal protein L23".

Further reading

  • Sun XX, Dai MS, Lu H (2007). "5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction". J. Biol. Chem. 282 (11): 8052–9. doi:10.1074/jbc.M610621200. PMID 17242401.
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
  • O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease". Gene. 286 (1): 73–9. doi:10.1016/S0378-1119(01)00808-3. PMID 11943462.
  • Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  • Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q16540 (39S ribosomal protein L23, mitochondrial) at the PDBe-KB.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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