40S ribosomal protein S8

Protein-coding gene in the species Homo sapiens
RPS8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4UJE, 4D5L, 3J7R, 4UJD, 5FLX, 4D61, 4UJC

Identifiers
AliasesRPS8, S8, ribosomal protein S8
External IDsOMIM: 600357; MGI: 98166; HomoloGene: 133143; GeneCards: RPS8; OMA:RPS8 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RPS8
Genomic location for RPS8
Band1p34.1Start44,775,251 bp[1]
End44,778,779 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for RPS8
Genomic location for RPS8
Band4|4 D1Start117,011,024 bp[2]
End117,013,440 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left ovary

  • right ovary

  • canal of the cervix

  • body of uterus

  • uterine tube

  • left adrenal cortex

  • ganglionic eminence

  • right uterine tube

  • right adrenal gland

  • lymph node
Top expressed in
  • ventricular zone

  • epiblast

  • ganglionic eminence

  • uterus

  • esophagus

  • ovary

  • embryo

  • ileum

  • duodenum

  • lens
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural constituent of ribosome
  • RNA binding
Cellular component
  • focal adhesion
  • nucleus
  • intracellular anatomical structure
  • ribosome
  • extracellular exosome
  • membrane
  • nucleoplasm
  • cytoplasm
  • endoplasmic reticulum
  • cytosol
  • cytosolic small ribosomal subunit
  • ribonucleoprotein complex
Biological process
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • SRP-dependent cotranslational protein targeting to membrane
  • viral transcription
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translational initiation
  • protein biosynthesis
  • rRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6202

20116

Ensembl

ENSG00000142937

ENSMUSG00000047675

UniProt

P62241

P62242

RefSeq (mRNA)

NM_001012

NM_009098

RefSeq (protein)

NP_001003

NP_033124

Location (UCSC)Chr 1: 44.78 – 44.78 MbChr 4: 117.01 – 117.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene.[5][6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142937 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047675 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Davies B, Fried M (Mar 1993). "The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1". Genomics. 15 (1): 68–75. doi:10.1006/geno.1993.1011. PMID 8432552.
  6. ^ a b "Entrez Gene: RPS8 ribosomal protein S8".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
  • Pogue-Geile K, Geiser JR, Shu M, et al. (1991). "Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein". Mol. Cell. Biol. 11 (8): 3842–9. doi:10.1128/mcb.11.8.3842. PMC 361167. PMID 1712897.
  • Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
  • Nicoloso M, Qu LH, Michot B, Bachellerie JP (1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". J. Mol. Biol. 260 (2): 178–95. doi:10.1006/jmbi.1996.0391. PMID 8764399.
  • Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Brenner C, Deplus R, Didelot C, et al. (2005). "Myc represses transcription through recruitment of DNA methyltransferase corepressor". EMBO J. 24 (2): 336–46. doi:10.1038/sj.emboj.7600509. PMC 545804. PMID 15616584.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
  • Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell. Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts


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