Mitochondrial ribosomal protein L10

Protein-coding gene in the species Homo sapiens
MRPL10
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J7Y, 3J9M

Identifiers
AliasesMRPL10, L10MT, MRP-L10, MRP-L8, MRPL8, RPML8, mitochondrial ribosomal protein L10
External IDsOMIM: 611825; MGI: 1333801; HomoloGene: 41665; GeneCards: MRPL10; OMA:MRPL10 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for MRPL10
Genomic location for MRPL10
Band17q21.32Start47,823,272 bp[1]
End47,831,541 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for MRPL10
Genomic location for MRPL10
Band11|11 DStart96,932,386 bp[2]
End96,940,039 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • left ventricle

  • muscle of thigh

  • myocardium of left ventricle

  • gastrocnemius muscle

  • cardiac muscle tissue of right atrium

  • deltoid muscle

  • tibialis anterior muscle

  • muscle layer of sigmoid colon

  • granulocyte
Top expressed in
  • yolk sac

  • right ventricle

  • brown adipose tissue

  • right kidney

  • adrenal gland

  • myocardium of ventricle

  • proximal tubule

  • granulocyte

  • epiblast

  • left lobe of liver
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • structural constituent of ribosome
  • RNA binding
Cellular component
  • ribosome
  • nucleoplasm
  • intracellular anatomical structure
  • mitochondrion
  • mitochondrial inner membrane
  • mitochondrial large ribosomal subunit
  • large ribosomal subunit
  • ribonucleoprotein complex
Biological process
  • mitochondrial translational elongation
  • protein biosynthesis
  • mitochondrial translational termination
  • ribosome biogenesis
  • mitochondrial translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

124995

107732

Ensembl

ENSG00000159111

ENSMUSG00000001445

UniProt

Q7Z7H8

Q3TBW2

RefSeq (mRNA)

NM_145255
NM_148887

NM_026154
NM_001357807
NM_001357808

RefSeq (protein)

NP_660298
NP_683685

NP_080430
NP_001344736
NP_001344737

Location (UCSC)Chr 17: 47.82 – 47.83 MbChr 11: 96.93 – 96.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L10, mitochondrial is a protein that in humans is encoded by the MRPL10 gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified two transcript variants that encode different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159111 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001445 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL (Nov 2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J Biol Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
  6. ^ a b "Entrez Gene: MRPL10 mitochondrial ribosomal protein L10".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wang CC, Kadota M, Nishigaki R, et al. (2004). "Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21". Biochem. Biophys. Res. Commun. 314 (2): 335–50. doi:10.1016/j.bbrc.2003.12.091. PMID 14733910.
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  • Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 273 (52): 34828–36. doi:10.1074/jbc.273.52.34828. PMID 9857009.
  • Piatyszek MA, Denslow ND, O'Brien TW (1988). "RNA binding proteins of the large subunit of bovine mitochondrial ribosomes". Nucleic Acids Res. 16 (6): 2565–83. doi:10.1093/nar/16.6.2565. PMC 336390. PMID 3129699.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q7Z7H8 (39S ribosomal protein L10, mitochondrial) at the PDBe-KB.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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