| BCL6 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1R28, 1R29, 1R2B, 2EN2, 2EOS, 2LCE, 2YRM, 3BIM, 3E4U, 3LBZ, 4CP3, 4U2M | | |
| Ідентифікатори |
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| Символи | BCL6, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51, B-cell CLL/lymphoma 6, B cell CLL/lymphoma 6, transcription repressor, BCL6 transcription repressor |
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| Зовнішні ІД | OMIM: 109565 MGI: 107187 HomoloGene: 7640 GeneCards: BCL6 |
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| Онтологія гена |
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| Молекулярна функція | • sequence-specific DNA binding
• DNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• intronic transcription regulatory region sequence-specific DNA binding
• chromatin binding
• зв'язування з іоном металу
• GO:0001948, GO:0016582 protein binding
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
• nucleic acid binding
• chromatin DNA binding
• identical protein binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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| Клітинна компонента | • replication fork
• клітинне ядро
• нуклеоплазма
• комплекс Ґольджі
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| Біологічний процес | • regulation of germinal center formation
• positive regulation of histone deacetylation
• negative regulation of T-helper 2 cell differentiation
• GO:0034613 protein localization
• negative regulation of mast cell cytokine production
• GO:0009373 regulation of transcription, DNA-templated
• процес імунної системи
• GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• negative regulation of cell differentiation
• germinal center formation
• negative regulation of Rho protein signal transduction
• negative regulation of isotype switching to IgE isotypes
• negative regulation of apoptotic process
• GO:1901227 negative regulation of transcription by RNA polymerase II
• transcription, DNA-templated
• type 2 immune response
• cellular response to DNA damage stimulus
• negative regulation of cell-matrix adhesion
• regulation of cell population proliferation
• positive regulation of B cell proliferation
• negative regulation of cell growth
• Rho protein signal transduction
• GO:0000767 cell morphogenesis
• Сперматогенез
• regulation of memory T cell differentiation
• positive regulation of neuron differentiation
• regulation of inflammatory response
• regulation of immune response
• positive regulation of apoptotic process
• negative regulation of type 2 immune response
• negative regulation of B cell apoptotic process
• B cell differentiation
• inflammatory response
• GO:0045996 negative regulation of transcription, DNA-templated
• actin cytoskeleton organization
• negative regulation of cell population proliferation
• negative regulation of Notch signaling pathway
• erythrocyte development
• negative regulation of cellular senescence
• regulation of apoptotic process
• negative regulation of mitotic cell cycle DNA replication
• positive regulation of regulatory T cell differentiation
• cytokine-mediated signaling pathway
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_001130845
NM_001134738
NM_001706
NM_138931 |
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| RefSeq (білок) | | NP_001124317
NP_001128210
NP_001697 |
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| Локус (UCSC) | Хр. 3: 187.72 – 187.75 Mb | Хр. 16: 23.78 – 23.81 Mb |
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| PubMed search | [1] | [2] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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