SGK2

Protein-coding gene in the species Homo sapiens
SGK2
Identifiers
AliasesSGK2, H-dJ138B7.2, serine/threonine kinase 2, serum/glucocorticoid regulated kinase 2
External IDsOMIM: 607589; MGI: 1351318; HomoloGene: 8446; GeneCards: SGK2; OMA:SGK2 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SGK2
Genomic location for SGK2
Band20q13.12Start43,558,968 bp[1]
End43,588,237 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SGK2
Genomic location for SGK2
Band2|2 H2Start162,829,250 bp[2]
End162,856,047 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • right lobe of liver

  • rectum

  • human kidney

  • C1 segment

  • renal medulla

  • duodenum

  • body of pancreas

  • kidney tubule

  • mucosa of ileum
Top expressed in
  • right kidney

  • human kidney

  • left lobe of liver

  • proximal tubule

  • pyloric antrum

  • mucous cell of stomach

  • epithelium of stomach

  • large intestine

  • ileum

  • intestinal villus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ATP binding
  • calcium channel regulator activity
  • sodium channel regulator activity
  • protein kinase activity
  • potassium channel regulator activity
  • kinase activity
  • chloride channel regulator activity
  • nucleotide binding
  • transferase activity
  • protein serine/threonine kinase activity
Cellular component
  • nucleus
  • intracellular anatomical structure
  • cytosol
  • cytoplasm
  • nucleoplasm
  • cellular component
Biological process
  • response to oxidative stress
  • positive regulation of transporter activity
  • regulation of cell population proliferation
  • ion transmembrane transport
  • protein phosphorylation
  • intracellular signal transduction
  • peptidyl-serine phosphorylation
  • regulation of apoptotic process
  • phosphorylation
  • regulation of cell growth
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10110

27219

Ensembl

ENSG00000101049

ENSMUSG00000017868

UniProt

Q9HBY8
Q5H8Y5

Q9QZS5

RefSeq (mRNA)

NM_170693
NM_001199264
NM_016276

NM_001291152
NM_001291154
NM_013731

RefSeq (protein)

NP_001186193
NP_057360
NP_733794

NP_001278081
NP_001278083
NP_038759

Location (UCSC)Chr 20: 43.56 – 43.59 MbChr 2: 162.83 – 162.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.[5][6]

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase (PI3K), which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101049 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017868 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kobayashi T, Deak M, Morrice N, Cohen P (Jan 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 (1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
  6. ^ a b "Entrez Gene: SGK2 serum/glucocorticoid regulated kinase 2".

Further reading

  • Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Sci. STKE. 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620. S2CID 25927734.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Gamper N, Fillon S, Feng Y, et al. (2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflügers Arch. 445 (1): 60–6. doi:10.1007/s00424-002-0873-2. PMID 12397388. S2CID 21073737.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Friedrich B, Feng Y, Cohen P, et al. (2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflügers Arch. 445 (6): 693–6. doi:10.1007/s00424-002-0993-8. PMID 12632189. S2CID 32511608.
  • Embark HM, Böhmer C, Vallon V, et al. (2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflügers Arch. 445 (5): 601–6. doi:10.1007/s00424-002-0982-y. PMID 12634932. S2CID 22981271.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Baltaev R, Strutz-Seebohm N, Korniychuk G, et al. (2005). "Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes". Pflügers Arch. 450 (1): 26–33. doi:10.1007/s00424-004-1369-z. PMID 15578212. S2CID 190895.
  • Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.

External links

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  • e
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
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IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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