CAMK2D

Protein-coding gene in the species Homo sapiens
CAMK2D
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2VN9, 2W2C, 2WEL, 3GP2

Identifiers
AliasesCAMK2D, CAMKD, calcium/calmodulin dependent protein kinase II delta
External IDsOMIM: 607708; MGI: 1341265; HomoloGene: 55561; GeneCards: CAMK2D; OMA:CAMK2D - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CAMK2D
Genomic location for CAMK2D
Band4q26Start113,418,054 bp[1]
End113,761,927 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for CAMK2D
Genomic location for CAMK2D
Band3|3 G1- G2Start126,389,951 bp[2]
End126,639,975 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • myocardium of left ventricle

  • lateral nuclear group of thalamus

  • cardiac muscle tissue of right atrium

  • middle temporal gyrus

  • Brodmann area 23

  • right ventricle

  • entorhinal cortex

  • tibialis anterior muscle

  • deltoid muscle

  • endothelial cell
Top expressed in
  • anterior amygdaloid area

  • neural layer of retina

  • lobe of cerebellum

  • cerebellar vermis

  • lateral septal nucleus

  • medial geniculate nucleus

  • dorsomedial hypothalamic nucleus

  • atrium

  • lateral hypothalamus

  • ventral tegmental area
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • kinase activity
  • ATP binding
  • protein kinase activity
  • titin binding
  • transferase activity
  • protein homodimerization activity
  • protein binding
  • nucleotide binding
  • sodium channel inhibitor activity
  • calmodulin-dependent protein kinase activity
  • protein serine/threonine kinase activity
  • transmembrane transporter binding
  • calmodulin binding
  • identical protein binding
Cellular component
  • endocytic vesicle membrane
  • membrane
  • sarcoplasmic reticulum membrane
  • plasma membrane
  • nucleoplasm
  • sarcoplasmic reticulum
  • sarcolemma
  • neuron projection
  • nucleus
  • cytoplasm
  • cytosol
  • calcium channel complex
Biological process
  • regulation of heart contraction
  • interferon-gamma-mediated signaling pathway
  • regulation of transcription by RNA polymerase II
  • regulation of membrane depolarization
  • positive regulation of cardiac muscle hypertrophy
  • protein phosphorylation
  • cellular response to calcium ion
  • regulation of cardiac muscle cell action potential involved in regulation of contraction
  • regulation of histone deacetylase activity
  • regulation of cellular localization
  • negative regulation of sodium ion transmembrane transport
  • phosphorylation
  • regulation of the force of heart contraction
  • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
  • regulation of ryanodine-sensitive calcium-release channel activity
  • negative regulation of sodium ion transmembrane transporter activity
  • MAPK cascade
  • protein complex oligomerization
  • regulation of cell growth
  • regulation of cellular response to heat
  • regulation of cell communication by electrical coupling involved in cardiac conduction
  • regulation of heart rate by cardiac conduction
  • nervous system development
  • cell differentiation
  • regulation of cell communication by electrical coupling
  • positive regulation of cardiac muscle cell apoptotic process
  • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
  • peptidyl-serine phosphorylation
  • peptidyl-threonine phosphorylation
  • endoplasmic reticulum calcium ion homeostasis
  • protein autophosphorylation
  • relaxation of cardiac muscle
  • cardiac muscle cell contraction
  • regulation of cardiac muscle cell action potential
  • regulation of relaxation of cardiac muscle
  • regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

817

108058

Ensembl

ENSG00000145349

ENSMUSG00000053819

UniProt

Q13557

Q6PHZ2

RefSeq (mRNA)
NM_001221
NM_172114
NM_172115
NM_172127
NM_172128

NM_172129
NM_001321566
NM_001321567
NM_001321568
NM_001321569
NM_001321570
NM_001321571
NM_001321572
NM_001321573
NM_001321574
NM_001321575
NM_001321576
NM_001321577
NM_001321578
NM_001321579
NM_001321580
NM_001321581
NM_001321582
NM_001321583
NM_001321584
NM_001321585
NM_001321586
NM_001321587
NM_001321588
NM_001321589
NM_001321590
NM_001321591
NM_001321592
NM_001396964
NM_001396965
NM_001396966
NM_001396967
NM_001399855
NM_001399856
NM_001399857
NM_001399858
NM_001399859
NM_001399860
NM_001399861
NM_001399862
NM_001399863
NM_001399864
NM_001399865

NM_001025438
NM_001025439
NM_001293663
NM_001293664
NM_001293665

NM_001293666
NM_023813
NM_001346635
NM_001346636

RefSeq (protein)
NP_001212
NP_001308495
NP_001308496
NP_001308497
NP_001308498

NP_001308499
NP_001308500
NP_001308501
NP_001308502
NP_001308503
NP_001308504
NP_001308505
NP_001308506
NP_001308507
NP_001308508
NP_001308509
NP_001308510
NP_001308511
NP_001308512
NP_001308513
NP_001308514
NP_001308515
NP_001308516
NP_001308517
NP_001308518
NP_001308519
NP_001308520
NP_001308521
NP_742112
NP_742113
NP_742125
NP_742126
NP_742127

NP_001020609
NP_001020610
NP_001280592
NP_001280593
NP_001280594

NP_001280595
NP_001333564
NP_001333565
NP_076302

Location (UCSC)Chr 4: 113.42 – 113.76 MbChr 3: 126.39 – 126.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.[5]

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca2+/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145349 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053819 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CAMK2D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta".

Further reading

  • Hook SS, Means AR (2001). "Ca2+/CaM-dependent kinases: from activation to function". Annu. Rev. Pharmacol. Toxicol. 41 (1): 471–505. doi:10.1146/annurev.pharmtox.41.1.471. PMID 11264466.
  • Yamamoto H (2002). "[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]". Tanpakushitsu Kakusan Koso. 47 (3): 241–7. PMID 11889801.
  • de Groot RP, den Hertog J, Vandenheede JR, et al. (1993). "Multiple and cooperative phosphorylation events regulate the CREM activator function". EMBO J. 12 (10): 3903–11. doi:10.1002/j.1460-2075.1993.tb06068.x. PMC 413673. PMID 8404858.
  • Tombes RM, Krystal GW (1997). "Identification of novel human tumor cell-specific CaMK-II variants". Biochim. Biophys. Acta. 1355 (3): 281–92. doi:10.1016/S0167-4889(96)00141-3. PMID 9060999.
  • Moyers JS, Bilan PJ, Zhu J, Kahn CR (1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. doi:10.1074/jbc.272.18.11832. PMID 9115241.
  • Möhlig M, Wolter S, Mayer P, et al. (1997). "Insulinoma cells contain an isoform of Ca2+/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles". Endocrinology. 138 (6): 2577–84. doi:10.1210/endo.138.6.5168. PMID 9165051.
  • Bauch A, Campbell KS, Reth M (1998). "Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta". Eur. J. Immunol. 28 (7): 2167–77. doi:10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L. PMID 9692886.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Hoch B, Meyer R, Hetzer R, et al. (1999). "Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium". Circ. Res. 84 (6): 713–21. doi:10.1161/01.res.84.6.713. PMID 10189359.
  • Tombes RM, Mikkelsen RB, Jarvis WD, Grant S (1999). "Downregulation of delta CaM kinase II in human tumor cells". Biochim. Biophys. Acta. 1452 (1): 1–11. doi:10.1016/S0167-4889(99)00113-5. PMID 10525155.
  • Rochlitz H, Voigt A, Lankat-Buttgereit B, et al. (2000). "Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells". Diabetologia. 43 (4): 465–73. doi:10.1007/s001250051330. PMID 10819240.
  • Inagaki N, Nishizawa M, Arimura N, et al. (2000). "Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons". J. Biol. Chem. 275 (35): 27165–71. doi:10.1074/jbc.M003751200. PMID 10852918.
  • Nair JS, DaFonseca CJ, Tjernberg A, et al. (2002). "Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 5971–6. Bibcode:2002PNAS...99.5971N. doi:10.1073/pnas.052159099. PMC 122886. PMID 11972023.
  • Mishra-Gorur K, Singer HA, Castellot JJ (2002). "The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II". J. Biol. Chem. 277 (37): 33537–40. doi:10.1074/jbc.C200342200. PMID 12145273.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gaertner TR, Kolodziej SJ, Wang D, et al. (2004). "Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II". J. Biol. Chem. 279 (13): 12484–94. doi:10.1074/jbc.M313597200. PMID 14722083.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.

External links

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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
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MAP3K (EC 2.7.11.25)
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
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