| Yıl | Film | Rol | Notlar |
| 1982 | The World According to Garp | Jenny Fields | |
| 1983 | The Big Chill | Sarah Cooper | |
| 1984 | The Natural | Iris Gaines | |
| The Stone Boy | Ruth Hillerman | |
| Greystoke: The Legend of Tarzan, Lord of the Apes | Jane Porter (Seslendirme) | |
| 1985 | Maxie | Jan / Maxie | |
| Jagged Edge | Teddy Barnes | |
| 1987 | Fatal Attraction | Alex Forrest | |
| 1988 | Dangerous Liaisons | Marquise Isabelle de Merteuil | |
| Light Years | Queen Ambisextra (Seslendirme) | |
| 1989 | Immediate Family | Linda Spector | |
| 1990 | Hamlet | Queen Gertrude | |
| Reversal of Fortune | Sunny von Bulow | |
| 1991 | Hook | Boo Box Pirate | cameo |
| Meeting Venus | Karin Anderson | |
| 1993 | The House of the Spirits | Ferula Trueba | |
| 1994 | The Paper | Alicia Clark | |
| 1996 | Mars Attacks! | First Lady Marsha Dale | |
| 101 Dalmatians | Cruella de Vil | |
| Mary Reilly | Mrs. Farraday | |
| 1997 | In & Out | Kendisi | cameo appearance |
| Air Force One | Vice President Kathryn Bennett | |
| Paradise Road | Adrienne Pargiter | |
| 1999 | Tarzan | Kala (Seslendirme) | |
| Cookie's Fortune | Camille Dixon | |
| 2000 | 102 Dalmatians | Cruella de Vil | |
| Things You Can Tell Just by Looking at Her | Dr. Elaine Keener | |
| 2001 | The Safety of Objects | Esther Gold | |
| 2003 | Le Divorce | Olivia Pace | |
| Roberto Benigni's Pinocchio | Blue Fairy (Seslendirme) | |
| 2004 | Heights | Diana | |
| The Stepford Wives | Claire Wellington | |
| 2005 | The Chumscrubber | Carrie Johnson | |
| Nine Lives | Maggie | |
| Hoodwinked | Granny (Seslendirme) | |
| 2007 | Thérèse Raquin | Madame | |
| Evening | Mrs. Wittenborn | |
| 2008 | Sunset Boulevard | Norma Desmond | |
| 2011 | Hoodwinked Too! Hood vs. Evil | Granny | Seslendirme |
| Albert Nobbs | Albert Nobbs | Also writer and producer |
| 2014 | Low Down | Gram | |
| Galaksinin Koruyucuları | Nova Prime Irani Rael | |
| 2015 | 5 to 7 | Arlene | |
| Anesthesia | Marcia Zarrow | |
| The Great Gilly Hopkins | Nonnie Hopkins | |
| 2016 | Warcraft | Alodi | Uncredited |
| The Girl with All the Gifts | Dr. Caroline Caldwell | |
| 2017 | Yedinci Hayat | Nicolette Cayman | |
| The Wilde Wedding | Eve Wilde | |
| The Wife | Joan Castleman | |
| Crooked House | Lady Edith | |
| Father Figures | Helen Baxter | |
| 2020 | Four Good Days | Deb | Post-production |
| TBA | Hillbilly Elegy | Mawmaw | Post-production |
