Nucleoporin 93

Protein-coding gene in the species Homo sapiens
NUP93
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5IJN, 5IJO

Identifiers
AliasesNUP93, NIC96, NPHS12, nucleoporin 93kDa, nucleoporin 93
External IDsOMIM: 614351; MGI: 1919055; HomoloGene: 40971; GeneCards: NUP93; OMA:NUP93 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for NUP93
Genomic location for NUP93
Band16q13Start56,730,118 bp[1]
End56,850,286 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for NUP93
Genomic location for NUP93
Band8|8 C5Start94,941,192 bp[2]
End95,043,855 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • left lobe of thyroid gland

  • gonad

  • right lobe of thyroid gland

  • right testis

  • left testis

  • testicle

  • oocyte

  • granulocyte
Top expressed in
  • somite

  • zygote

  • yolk sac

  • mandibular prominence

  • primitive streak

  • epiblast

  • maxillary prominence

  • abdominal wall

  • secondary oocyte

  • tail of embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • structural constituent of nuclear pore
  • protein binding
Cellular component
  • nuclear membrane
  • membrane
  • nuclear periphery
  • nuclear pore
  • nucleus
  • nuclear envelope
  • host cell
Biological process
  • mRNA transport
  • viral transcription
  • protein sumoylation
  • mitotic nuclear membrane disassembly
  • regulation of cellular response to heat
  • protein transport
  • viral process
  • intracellular transport of virus
  • nuclear pore complex assembly
  • negative regulation of hydrogen peroxide-induced cell death
  • tRNA export from nucleus
  • glomerular visceral epithelial cell migration
  • nuclear envelope organization
  • mRNA export from nucleus
  • renal system development
  • positive regulation of SMAD protein signal transduction
  • SMAD protein signal transduction
  • glomerular visceral epithelial cell development
  • regulation of gene silencing by miRNA
  • poly(A)+ mRNA export from nucleus
  • regulation of glycolytic process
  • transport
  • protein import into nucleus
  • nucleocytoplasmic transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9688

71805

Ensembl

ENSG00000102900

ENSMUSG00000032939

UniProt

Q8N1F7

Q8BJ71

RefSeq (mRNA)

NM_001242795
NM_001242796
NM_014669

NM_172410
NM_001357266
NM_001357267
NM_001357268

RefSeq (protein)

NP_001229724
NP_001229725
NP_055484

NP_765998
NP_001344195
NP_001344196
NP_001344197

Location (UCSC)Chr 16: 56.73 – 56.85 MbChr 8: 94.94 – 95.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102900 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032939 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Grandi P, Dang T, Pane N, Shevchenko A, Mann M, Forbes D, Hurt E (Dec 1997). "Nup93, a Vertebrate Homologue of Yeast Nic96p, Forms a Complex with a Novel 205-kDa Protein and Is Required for Correct Nuclear Pore Assembly". Mol Biol Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
  6. ^ Shah S, Tugendreich S, Forbes D (May 1998). "Major Binding Sites for the Nuclear Import Receptor Are the Internal Nucleoporin Nup153 and the Adjacent Nuclear Filament Protein Tpr". J Cell Biol. 141 (1): 31–49. doi:10.1083/jcb.141.1.31. PMC 2132719. PMID 9531546.
  7. ^ "Entrez Gene: NUP93 nucleoporin 93kDa".

Further reading

  • Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Patre M, Tabbert A, Hermann D, et al. (2006). "Caspases target only two architectural components within the core structure of the nuclear pore complex". J. Biol. Chem. 281 (2): 1296–304. doi:10.1074/jbc.M511717200. hdl:11858/00-001M-0000-0028-3A8A-9. PMID 16286466.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Nuclear pore complex protein Nup93



Stub icon

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e