Nucleoporin 88

Protein-coding gene in the species Homo sapiens

NUP88

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
7R5J, 7R5K, 7TDZ, 7VOP

Identifiers

Aliases

NUP88, nucleoporin 88, FADS4

External IDs

OMIM: 602552; MGI: 104900; HomoloGene: 1901; GeneCards: NUP88; OMA:NUP88 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17p13.2	Start	5,360,963 bp^[1]
Band	17p13.2	End	5,419,676 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 B4\|11 43.21 cM	Start	70,833,884 bp^[2]
Band	11 B4\|11 43.21 cM	End	70,860,799 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right testis

left testis

oocyte

gonad

right lobe of liver

secondary oocyte

sperm

mucosa of transverse colon

left lobe of thyroid gland

ventricular zone

Top expressed in

tail of embryo

zygote

genital tubercle

secondary oocyte

medial ganglionic eminence

spermatocyte

primary oocyte

abdominal wall

ventricular zone

epiblast

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transporter activity structural constituent of nuclear pore
Cellular component	cytosol nuclear pore nucleoplasm nucleus host cell
Biological process	mRNA transport protein import into nucleus protein transport viral process mRNA export from nucleus mitotic cell cycle ribosomal large subunit export from nucleus ribosomal small subunit export from nucleus nucleocytoplasmic transport protein export from nucleus regulation of glycolytic process tRNA export from nucleus protein sumoylation viral transcription regulation of gene silencing by miRNA intracellular transport of virus regulation of cellular response to heat
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4927


19069

Ensembl


ENSG00000108559


ENSMUSG00000040667

UniProt


Q99567


Q8CEC0

RefSeq (mRNA)


NM_002532 NM_001320653


NM_001083331 NM_001276406 NM_172394

RefSeq (protein)


NP_001307582 NP_002523


NP_001076800 NP_001263335 NP_765982

Location (UCSC)

Chr 17: 5.36 – 5.42 Mb

Chr 11: 70.83 – 70.86 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.^[5]^[6]

Function

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.^[6]

Interactions

NUP88 has been shown to interact with NUP98.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108559 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040667 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fornerod M, van Deursen J, van Baal S, Reynolds A, Davis D, Murti KG, Fransen J, Grosveld G (Mar 1997). "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88". EMBO J. 16 (4): 807–16. doi:10.1093/emboj/16.4.807. PMC 1169681. PMID 9049309.
^ ^a ^b "Entrez Gene: NUP88 nucleoporin 88kDa".
^ Griffis ER, Xu S, Powers MA (Feb 2003). "Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes". Mol. Biol. Cell. 14 (2): 600–10. doi:10.1091/mbc.E02-09-0582. PMC 149995. PMID 12589057.

Stoffler D, Fahrenkrog B, Aebi U (1999). "The nuclear pore complex: from molecular architecture to functional dynamics". Curr. Opin. Cell Biol. 11 (3): 391–401. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558.
Hood JK, Silver PA (2000). "Diverse nuclear transport pathways regulate cell proliferation and oncogenesis". Biochim. Biophys. Acta. 1471 (1): M31–41. doi:10.1016/s0304-419x(00)00018-4. PMID 10967423.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Fornerod M, van Baal S, Valentine V, Shapiro DN, Grosveld G (1997). "Chromosomal localization of genes encoding CAN/Nup214-interacting proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32". Genomics. 42 (3): 538–40. doi:10.1006/geno.1997.4767. PMID 9205132.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Boer J, Bonten-Surtel J, Grosveld G (1998). "Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis". Mol. Cell. Biol. 18 (3): 1236–47. doi:10.1128/mcb.18.3.1236. PMC 108836. PMID 9488438.
Martínez N, Alonso A, Moragues MD, Pontón J, Schneider J (1999). "The nuclear pore complex protein Nup88 is overexpressed in tumor cells". Cancer Res. 59 (21): 5408–11. PMID 10554006.
Gould VE, Martinez N, Orucevic A, Schneider J, Alonso A (2000). "A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development". Am. J. Pathol. 157 (5): 1605–13. doi:10.1016/S0002-9440(10)64798-0. PMC 1885726. PMID 11073820.
Wu X, Kasper LH, Mantcheva RT, Mantchev GT, Springett MJ, van Deursen JM (2001). "Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3191–6. Bibcode:2001PNAS...98.3191W. doi:10.1073/pnas.051631598. PMC 30629. PMID 11248054.
Gould VE, Orucevic A, Zentgraf H, Gattuso P, Martinez N, Alonso A (2002). "Nup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis". Hum. Pathol. 33 (5): 536–44. doi:10.1053/hupa.2002.124785. PMID 12094380.
Griffis ER, Xu S, Powers MA (2003). "Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes". Mol. Biol. Cell. 14 (2): 600–10. doi:10.1091/mbc.E02-09-0582. PMC 149995. PMID 12589057.
Agudo D, Gómez-Esquer F, Martínez-Arribas F, Núñez-Villar MJ, Pollán M, Schneider J (2004). "Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer". Int. J. Cancer. 109 (5): 717–20. doi:10.1002/ijc.20034. PMID 14999780. S2CID 28081933.
Schneider J, Linares R, Martínez-Arribas F, Moragues MD, Nuñez-Villar MJ, Palomar MA, Pontón J (2004). "Developing chick embryos express a protein which shares homology with the nuclear pore complex protein Nup88 present in human tumors". Int. J. Dev. Biol. 48 (4): 339–42. doi:10.1387/ijdb.031748js. PMID 15300515.
Bernad R, Engelsma D, Sanderson H, Pickersgill H, Fornerod M (2006). "Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export". J. Biol. Chem. 281 (28): 19378–86. doi:10.1074/jbc.M512585200. PMID 16675447.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.