EPH receptor A1
Protein-coding gene in the species Homo sapiens
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| Aliases | EPHA1, Epha1, 5730453L17Rik, AL033318, Eph, Esk, EPHT, EPHT1, EPH receptor A1, EPH | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 179610; MGI: 107381; HomoloGene: 3835; GeneCards: EPHA1; OMA:EPHA1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.[5][6]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.[6]
References
- ^ a b c ENSG00000284816 GRCh38: Ensembl release 89: ENSG00000146904, ENSG00000284816 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029859 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.
- ^ a b "Entrez Gene: EPHA1 EPH receptor A1".
Further reading
- Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
- Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
- Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID 10207129.
- Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 9780123646002. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
- Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. S2CID 205014301.
- Hirai H, Maru Y, Hagiwara K, et al. (1988). "A novel putative tyrosine kinase receptor encoded by the eph gene". Science. 238 (4834): 1717–20. doi:10.1126/science.2825356. PMID 2825356.
- Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474. S2CID 1075856.
- Owshalimpur D, Kelley MJ (1999). "Genomic structure of the EPHA1 receptor tyrosine kinase gene". Mol. Cell. Probes. 13 (3): 169–73. doi:10.1006/mcpr.1999.0228. PMID 10369740.
- Kalo MS, Pasquale EB (October 1999). "Signal transfer by eph receptors". Cell and Tissue Research. 298 (1): 1–9. doi:10.1007/pl00008807. PMID 10502115. S2CID 1241074.
- Coulthard MG, Lickliter JD, Subanesan N, et al. (2002). "Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues". Growth Factors. 18 (4): 303–17. doi:10.3109/08977190109029118. PMID 11519828. S2CID 43039239.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
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PDB gallery
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1x5a: The solution structure of the second fibronectin type III domain of mouse Ephrin type-A receptor 1
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