DTX2

Protein-coding gene in the species Homo sapiens
DTX2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1V87

Identifiers
AliasesDTX2, RNF58, deltex 2, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 2
External IDsOMIM: 613141; MGI: 1921448; HomoloGene: 56904; GeneCards: DTX2; OMA:DTX2 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for DTX2
Genomic location for DTX2
Band7q11.23Start76,461,676 bp[1]
End76,505,995 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for DTX2
Genomic location for DTX2
Band5|5 G2Start136,023,654 bp[2]
End136,061,726 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • olfactory zone of nasal mucosa

  • sural nerve

  • right testis

  • minor salivary glands

  • left testis

  • blood

  • skin of leg

  • skin of abdomen

  • vagina
Top expressed in
  • secondary oocyte

  • primary oocyte

  • zygote

  • Rostral migratory stream

  • condyle

  • internal carotid artery

  • fossa

  • external carotid artery

  • hair follicle

  • motor neuron
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • protein binding
  • metal ion binding
  • transferase activity
Cellular component
  • cytoplasm
  • nuclear membrane
  • nucleus
  • nucleoplasm
Biological process
  • Notch signaling pathway
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

113878

74198

Ensembl

ENSG00000282379
ENSG00000091073

ENSMUSG00000004947

UniProt

Q86UW9

Q8R3P2

RefSeq (mRNA)

NM_001102594
NM_001102595
NM_001102596
NM_020892

NM_001256096
NM_001256097
NM_001256098
NM_023742

RefSeq (protein)

NP_001096064
NP_001096065
NP_001096066
NP_065943

NP_001243025
NP_001243026
NP_001243027
NP_076231

Location (UCSC)Chr 7: 76.46 – 76.51 MbChr 5: 136.02 – 136.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.[5]

DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A.[6]

References

  1. ^ a b c ENSG00000091073 GRCh38: Ensembl release 89: ENSG00000282379, ENSG00000091073 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004947 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: DTX2 deltex homolog 2 (Drosophila)".
  6. ^ Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.

Further reading

  • Matsuno K, Diederich RJ, Go MJ, et al. (1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development. 121 (8): 2633–44. doi:10.1242/dev.121.8.2633. PMID 7671825.
  • Kishi N, Tang Z, Maeda Y, et al. (2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". Int. J. Dev. Neurosci. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752. S2CID 21859491.
  • Yamamoto N, Yamamoto S, Inagaki F, et al. (2002). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". J. Biol. Chem. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  • Hiller M, Huse K, Szafranski K, et al. (2007). "Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing". Am. J. Hum. Genet. 78 (2): 291–302. doi:10.1086/500151. PMC 1380236. PMID 16400609.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Yi Z, Yi T, Wu Z (2007). "cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos". DNA Seq. 17 (3): 175–80. doi:10.1080/10425170600857616. PMID 17286044. S2CID 26424595.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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