HIVEP1

Protein-coding gene in the species Homo sapiens
HIVEP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1BBO, 4ZNF

Identifiers
AliasesHIVEP1, CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A, human immunodeficiency virus type I enhancer binding protein 1, HIVEP zinc finger 1
External IDsOMIM: 194540; MGI: 96100; HomoloGene: 1596; GeneCards: HIVEP1; OMA:HIVEP1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HIVEP1
Genomic location for HIVEP1
Band6p24.1Start12,008,762 bp[1]
End12,164,999 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for HIVEP1
Genomic location for HIVEP1
Band13 A4|13 20.72 cMStart42,205,497 bp[2]
End42,346,013 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • cartilage tissue

  • sural nerve

  • epithelium of colon

  • superficial temporal artery

  • jejunal mucosa

  • seminal vesicula

  • oral cavity

  • right lobe of liver

  • caput epididymis
Top expressed in
  • zygote

  • genital tubercle

  • secondary oocyte

  • primary oocyte

  • tail of embryo

  • medial dorsal nucleus

  • lateral geniculate nucleus

  • primary motor cortex

  • habenula

  • medial geniculate nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • cytoplasm
  • mitochondrion
  • nucleus
  • nucleoplasm
  • nuclear body
Biological process
  • multicellular organism development
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • signal transduction
  • transcription, DNA-templated
  • BMP signaling pathway
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3096

110521

Ensembl

ENSG00000095951

ENSMUSG00000021366

UniProt

P15822

Q03172

RefSeq (mRNA)

NM_002114

NM_007772

RefSeq (protein)

NP_002105

NP_031798

Location (UCSC)Chr 6: 12.01 – 12.16 MbChr 13: 42.21 – 42.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.[5][6]

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095951 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021366 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gaynor RB, Muchardt C, Diep A, Mohandas TK, Sparkes RS, Lusis AJ (Jul 1991). "Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24". Genomics. 9 (4): 758–61. doi:10.1016/0888-7543(91)90371-K. PMID 2037300.
  6. ^ a b "Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1".

Further reading

  • Omichinski JG, Clore GM, Robien M, et al. (1992). "High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1". Biochemistry. 31 (16): 3907–17. doi:10.1021/bi00131a004. PMID 1567844.
  • Nakamura T, Donovan DM, Hamada K, et al. (1990). "Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes". Mol. Cell. Biol. 10 (7): 3700–8. doi:10.1128/mcb.10.7.3700. PMC 360816. PMID 1694016.
  • Muchardt C, Seeler JS, Nirula A, et al. (1992). "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products". J. Virol. 66 (1): 244–50. doi:10.1128/JVI.66.1.244-250.1992. PMC 238281. PMID 1727488.
  • Fan CM, Maniatis T (1990). "A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence". Genes Dev. 4 (1): 29–42. doi:10.1101/gad.4.1.29. PMID 2106471.
  • Baldwin AS, LeClair KP, Singh H, Sharp PA (1990). "A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes". Mol. Cell. Biol. 10 (4): 1406–14. doi:10.1128/mcb.10.4.1406. PMC 362243. PMID 2108316.
  • Omichinski JG, Clore GM, Appella E, et al. (1991). "High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution". Biochemistry. 29 (40): 9324–34. doi:10.1021/bi00492a004. PMID 2248949.
  • Maekawa T, Sakura H, Sudo T, Ishii S (1989). "Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1". J. Biol. Chem. 264 (25): 14591–3. doi:10.1016/S0021-9258(18)63733-0. PMID 2504707.
  • Otsuka M, Fujita M, Aoki T, et al. (1995). "Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B". J. Med. Chem. 38 (17): 3264–70. doi:10.1021/jm00017a011. PMID 7650680.
  • Seeler JS, Muchardt C, Suessle A, Gaynor RB (1994). "Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression". J. Virol. 68 (2): 1002–9. doi:10.1128/JVI.68.2.1002-1009.1994. PMC 236538. PMID 8289330.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Wissmüller S, Kosian T, Wolf M, et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • v
  • t
  • e
  • 1bbo: HIGH-RESOLUTION SOLUTION STRUCTURE OF THE DOUBLE CYS2*HIS2 ZINC FINGER FROM THE HUMAN ENHANCER BINDING PROTEIN MBP-1
    1bbo: HIGH-RESOLUTION SOLUTION STRUCTURE OF THE DOUBLE CYS2*HIS2 ZINC FINGER FROM THE HUMAN ENHANCER BINDING PROTEIN MBP-1
  • 3znf: HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION
    3znf: HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION
  • 4znf: HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION
    4znf: HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF A SINGLE ZINC FINGER FROM A HUMAN ENHANCER BINDING PROTEIN IN SOLUTION

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
  • HIVEP1
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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