CEP97

Protein-coding gene in the species Homo sapiens
CEP97
Identifiers
AliasesCEP97, 2810403B08Rik, LRRIQ2, centrosomal protein 97
External IDsOMIM: 615864; MGI: 1921451; HomoloGene: 11579; GeneCards: CEP97; OMA:CEP97 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CEP97
Genomic location for CEP97
Band3q12.3Start101,724,593 bp[1]
End101,770,562 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for CEP97
Genomic location for CEP97
Band16|16 C1.1Start55,720,251 bp[2]
End55,755,218 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • endothelial cell

  • mucosa of paranasal sinus

  • inferior ganglion of vagus nerve

  • oocyte

  • internal globus pallidus

  • secondary oocyte

  • superior vestibular nucleus

  • subthalamic nucleus

  • ventricular zone
Top expressed in
  • Rostral migratory stream

  • hand

  • otolith organ

  • utricle

  • thymus

  • cumulus cell

  • blood

  • pineal gland

  • ciliary body

  • spermatocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • calmodulin binding
Cellular component
  • centrosome
  • cytoskeleton
  • microtubule organizing center
  • cytoplasm
  • cytosol
  • protein-containing complex
Biological process
  • cell projection organization
  • negative regulation of cilium assembly
  • regulation of mitotic spindle assembly
  • ciliary basal body-plasma membrane docking
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79598

74201

Ensembl

ENSG00000182504

ENSMUSG00000022604

UniProt

Q8IW35

Q9CZ62

RefSeq (mRNA)

NM_001303401
NM_024548

NM_001159364
NM_001159365
NM_001159366
NM_028815

RefSeq (protein)

NP_001290330
NP_078824

NP_001152836
NP_001152837
NP_001152838
NP_083091

Location (UCSC)Chr 3: 101.72 – 101.77 MbChr 16: 55.72 – 55.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein of 97 kDa (Cep97), also known as leucine-rich repeat and IQ domain-containing protein 2 (LRRIQ2), is a protein that in humans is encoded by the CEP97 gene.[5]

Cep97 along with CP110 inhibit generation of cilia.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182504 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022604 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: centrosomal protein 97kDa".
  6. ^ Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007). "Cep97 and CP110 suppress a cilia assembly program". Cell. 130 (4): 678–690. doi:10.1016/j.cell.2007.06.027. PMID 17719545. S2CID 17974875.

External links

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Svendsen JM, Smogorzewska A, Sowa ME, et al. (2009). "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair". Cell. 138 (1): 63–77. doi:10.1016/j.cell.2009.06.030. PMC 2720686. PMID 19596235.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Bettencourt-Dias M, Carvalho-Santos Z (2008). "Double life of centrioles: CP110 in the spotlight". Trends Cell Biol. 18 (1): 8–11. doi:10.1016/j.tcb.2007.11.002. PMID 18068367.
  • Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
  • Tsang WY, Spektor A, Vijayakumar S, et al. (2009). "Cep76, a centrosomal protein that specifically restrains centriole reduplication". Dev. Cell. 16 (5): 649–660. doi:10.1016/j.devcel.2009.03.004. PMC 4062978. PMID 19460342.
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