CEP350

Protein-coding gene in the species Homo sapiens
CEP350
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2COZ

Identifiers
AliasesCEP350, CAP350, GM133, centrosomal protein 350
External IDsOMIM: 617870; MGI: 1921331; HomoloGene: 8879; GeneCards: CEP350; OMA:CEP350 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CEP350
Genomic location for CEP350
Band1q25.2Start179,954,773 bp[1]
End180,114,875 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CEP350
Genomic location for CEP350
Band1|1 G3Start155,720,710 bp[2]
End155,849,001 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • trabecular bone

  • nipple

  • left testis

  • Achilles tendon

  • right testis

  • optic nerve

  • pancreatic ductal cell

  • jejunal mucosa

  • gingival epithelium
Top expressed in
  • medullary collecting duct

  • epithelium of stomach

  • ciliary body

  • pyloric antrum

  • retinal pigment epithelium

  • triceps brachii muscle

  • vastus lateralis muscle

  • Epithelium of choroid plexus

  • temporal muscle

  • mucous cell of stomach
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • microtubule binding
  • protein binding
Cellular component
  • centrosome
  • spindle
  • cytoskeleton
  • membrane
  • nucleus
  • microtubule organizing center
  • cytoplasm
  • cell projection
  • centriole
Biological process
  • microtubule anchoring
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9857

74081

Ensembl

ENSG00000135837

ENSMUSG00000033671

UniProt

Q5VT06

E9Q309

RefSeq (mRNA)

NM_014810

NM_001039184

RefSeq (protein)

NP_055625

NP_001034273

Location (UCSC)Chr 1: 179.95 – 180.11 MbChr 1: 155.72 – 155.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.[5][6][7]

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.[8]

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135837 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033671 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring". Mol Biol Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
  6. ^ Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350". J Cell Sci. 118 (Pt 1): 175–86. doi:10.1242/jcs.01600. PMID 15615782.
  7. ^ a b "Entrez Gene: CEP350 centrosomal protein 350kDa".
  8. ^ Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly". PLOS ONE. 3 (12): e3855. Bibcode:2008PLoSO...3.3855L. doi:10.1371/journal.pone.0003855. PMC 2586089. PMID 19052644.

External links

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
  • Makalowska I, Sood R, Faruque MU, et al. (2002). "Identification of six novel genes by experimental validation of GeneMachine predicted genes". Gene. 284 (1–2): 203–13. doi:10.1016/S0378-1119(01)00897-6. PMID 11891061.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Hoppeler-Lebel A, Celati C, Bellett G, et al. (2007). "Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex". J. Cell Sci. 120 (Pt 18): 3299–308. doi:10.1242/jcs.013102. PMID 17878239.
  • v
  • t
  • e
  • 2coz: Solution structure of the CAP-Gly domain in human centrosome-associated protein CAP350
    2coz: Solution structure of the CAP-Gly domain in human centrosome-associated protein CAP350


Stub icon

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e