Bimakalim
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Preferred IUPAC name 2,2-Dimethyl-4-(2-oxopyridin-1(2H)-yl)-2H-1-benzopyran-6-carbonitrile | |
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Chemical formula | C17H14N2O2 |
Molar mass | 278.311 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Bimakalim is a potassium channel opener.[1] It can be prepared from 2-acetyl-4-cyanophenol .[2]
References
- ^ Puddu, Paolo Emilio; Garlid, Keith D; Monti, Francesco; Iwashiro, Katsunori; Picard, Sandra; Dawodu, Amos Adeyemo; Criniti, Anna; Ruvolo, Giovanni; Campa, Pietro Paolo (2006). "Bimakalim: A Promising KATP Channel Activating Agent". Cardiovascular Drug Reviews. 18: 25. doi:10.1111/j.1527-3466.2000.tb00031.x.
- ^ Bergmann, Rolf; Gericke, Rolf (1990). "Synthesis and antihypertensive activity of 4-(1,2-dihydro-2-oxo-1-pyridyl)-2H-1-benzopyrans and related compounds, new potassium channel activators". Journal of Medicinal Chemistry. 33 (2). American Chemical Society (ACS): 492–504. doi:10.1021/jm00164a005. ISSN 0022-2623.
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Ion channel modulators
VGKCsTooltip Voltage-gated potassium channels |
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IRKsTooltip Inwardly rectifying potassium channel |
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KCaTooltip Calcium-activated potassium channel |
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K2PsTooltip Tandem pore domain potassium channel |
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VGSCsTooltip Voltage-gated sodium channels |
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ENaCTooltip Epithelial sodium channel |
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ASICsTooltip Acid-sensing ion channel |
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CaCCsTooltip Calcium-activated chloride channel |
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator |
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Unsorted |
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TRPsTooltip Transient receptor potential channels |
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LGICsTooltip Ligand gated ion channels |
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See also: Receptor/signaling modulators • Transient receptor potential channel modulators
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