Almokalant
Chemical compound
- None
- 4-(3-{Ethyl[3-(propane-1-sulfinyl)propyl]amino}-2-hydroxypropoxy)benzonitrile
- 123955-10-2 Y
- 3033962
- 2298526 Y
- I9NG89L275
- ChEMBL362103 Y
- DTXSID40869693
- Interactive image
- O=S(CCC)CCCN(CC)CC(O)COc1ccc(C#N)cc1
InChI
- InChI=1S/C18H28N2O3S/c1-3-11-24(22)12-5-10-20(4-2)14-17(21)15-23-18-8-6-16(13-19)7-9-18/h6-9,17,21H,3-5,10-12,14-15H2,1-2H3 Y
- Key:ZMHOBBKJBYLXFR-UHFFFAOYSA-N Y
Almokalant is a drug used to treat arrhythmia.[1] It is a potassium channel blocker.[1] It has been found to have teratogenic effects in rats.[2]
See also
- Vernakalant
References
- ^ a b Wiesfeld AC, Crijns HJ, Bergstrand RH, Almgren O, Hillege HL, Lie KI (October 1993). "Torsades de pointes with Almokalant, a new class III antiarrhythmic drug". American Heart Journal. 126 (4): 1008–1011. doi:10.1016/0002-8703(93)90726-p. PMID 8213422.
- ^ Wellfelt K, Sköld AC, Wallin A, Danielsson BR (1999-04-01). "Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species". Reproductive Toxicology. 13 (2): 93–101. doi:10.1016/s0890-6238(98)00066-5. PMID 10213516.
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