Inosine monophosphate synthase

ATIC
Cấu trúc được biết đến
PDBTìm trên Human UniProt: PDBe RCSB
Danh sách mã id PDB

1P4R, 1PKX, 1PL0

Mã định danh
Danh phápATIC, AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ID ngoàiOMIM: 601731 HomoloGene: 2983 GeneCards: ATIC
Mẫu hình biểu hiện RNA
Thêm nguồn tham khảo về sự biểu hiện
Bản thể gen
Chức năng phân tử• transferase activity
• protein homodimerization activity
• IMP cyclohydrolase activity
• catalytic activity
• phosphoribosylaminoimidazolecarboxamide formyltransferase activity
• hydrolase activity
• cadherin binding
Thành phần tế bào• cytosol
• membrane
• Ty thể
• extracellular exosome
• Màng tế bào
Quá trình sinh học• purine nucleotide biosynthetic process
• dihydrofolate metabolic process
• 'de novo' IMP biosynthetic process
• brainstem development
• ribonucleotide metabolic process
• cerebellum development
• nucleoside metabolic process
• tetrahydrofolate biosynthetic process
• animal organ regeneration
• response to inorganic substance
• cerebral cortex development
• purine ribonucleoside monophosphate biosynthetic process
• trao đổi chất
• nucleobase-containing compound metabolic process
• cellular response to interleukin-7
Nguồn: Amigo / QuickGO
Gen cùng nguồn
LoàiNgườiChuột
Entrez

471

n/a

Ensembl

ENSG00000138363

n/a

UniProt

P31939

n/a

RefSeq (mRNA)

NM_004044

n/a

RefSeq (protein)

NP_004035

n/a

Vị trí gen (UCSC)n/an/a
PubMed[1]n/a
Wikidata
Xem/Sửa Người

Protein sinh tổng hợp purin BURal PURH là một protein được mã hóa bởi gen ATIC ở người.[2][3][4]

ATIC mã hóa một enzyme tạo ra inosine monophosphate từ aminoimidazole carboxamide ribonucleotide.

Protein này có hai chức năng:

  • EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
  • EC 3.5.4.10 - IMP cyclohydrolase

Tham khảo

  1. ^ “Human PubMed Reference:”.
  2. ^ Rayl EA, Moroson BA, Beardsley GP (tháng 3 năm 1996). “The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping”. J Biol Chem. 271 (4): 2225–33. doi:10.1074/jbc.271.4.2225. PMID 8567683.
  3. ^ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (tháng 11 năm 1997). “Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase”. J Biochem. 122 (2): 309–13. doi:10.1093/oxfordjournals.jbchem.a021754. PMID 9378707.
  4. ^ “Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase”.

Đọc thêm

  • Rasmussen HH, van Damme J, Puype M, và đồng nghiệp (1993). “Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes”. Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
  • Yamauchi M, Seki N, Mita K, và đồng nghiệp (1996). “Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript”. DNA Res. 2 (6): 269–75. doi:10.1093/dnares/2.6.269. PMID 8867801.
  • Beardsley GP, Rayl EA, Gunn K, và đồng nghiệp (1998). “Structure and functional relationships in human pur H”. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 431: 221–6. doi:10.1007/978-1-4615-5381-6_43. ISBN 978-0-306-45778-4. PMID 9598063.
  • Vergis JM, Bulock KG, Fleming KG, Beardsley GP (2001). “Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity”. J. Biol. Chem. 276 (11): 7727–33. doi:10.1074/jbc.M009940200. PMID 11096114.
  • Bulock KG, Beardsley GP, Anderson KS (2002). “The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling”. J. Biol. Chem. 277 (25): 22168–74. doi:10.1074/jbc.M111964200. PMID 11948179.
  • Strausberg RL, Feingold EA, Grouse LH, và đồng nghiệp (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cheong CG, Wolan DW, Greasley SE, và đồng nghiệp (2004). “Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates”. J. Biol. Chem. 279 (17): 18034–45. doi:10.1074/jbc.M313691200. PMID 14966129.
  • Marie S, Heron B, Bitoun P, và đồng nghiệp (2004). “AICA-Ribosiduria: A Novel, Neurologically Devastating Inborn Error of Purine Biosynthesis Caused by Mutation of ATIC”. Am. J. Hum. Genet. 74 (6): 1276–81. doi:10.1086/421475. PMC 1182092. PMID 15114530.
  • Dervieux T, Furst D, Lein DO, và đồng nghiệp (2004). “Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis”. Arthritis Rheum. 50 (9): 2766–74. doi:10.1002/art.20460. PMID 15457444.
  • Gerhard DS, Wagner L, Feingold EA, và đồng nghiệp (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ewing RM, Chu P, Elisma F, và đồng nghiệp (2007). “Large-scale mapping of human protein–protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Liên kết ngoài

  • MeSH Inosine+monophosphate+synthase
  • x
  • t
  • s
Chuyển hóa purine
Đồng hóa
R5P→IMP:
IMP→AMP:
  • Adenylosuccinate synthase
  • Adenylosuccinate lyase
  • Ngược
IMP→GMP:
Cứu vãn nucleotide
Dị hóa
Chuyển hóa pyrimidine
Đồng hóa
  • CAD
    • Carbamoyl phosphate synthase II
    • Aspartate carbamoyltransferase
    • Dihydroorotase
  • Dihydroorotate dehydrogenase
  • Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase
  • CTP synthetase
Dị hóa
  • Dihydropyrimidine dehydrogenase
  • Dihydropyrimidinase/DPYS
  • Beta-ureidopropionase/UPB1
Deoxyribonucleotide
  • Ribonucleotide reductase
  • Nucleoside-diphosphate kinase
  • DCMP deaminase
  • Thymidylate synthase
  • Dihydrofolate reductase