PRRP

Prolaktin-oslobađajući hormonski receptor

Identifikatori

PRLHR; GPR10; GR3; MGC126539; MGC126541; PrRPR

Vanjski ID

OMIM: 600895 MGI: 2135956 HomoloGene: 3134 IUPHAR: PRRP GeneCards: PRLHR Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost neuropeptid Y receptora
Celularna komponenta	• integralno sa ćelijskom membranom • membrana
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora • trudnoća • način ishrane • hormonski metabolički proces

Ortolozi

Vrsta

Čovek

Miš

Entrez

2834

226278

Ensembl

ENSG00000119973

ENSMUSG00000045052

UniProt

P49683

Q059H6

RefSeq (mRNA)

NM_004248

NM_201615

RefSeq (protein)

NP_004239

NP_963909

Lokacija (UCSC)

Chr 10:
120.34 - 120.34 Mb

Chr 19:
60.52 - 60.52 Mb

PubMed pretraga

[1]

[2]

PRRP, prolaktin-oslobađajući hormonski receptor, je G-protein spregnuti receptor^[1] koji vezuje prolaktin oslobađajući hormon.^[2]

PRLHR je 7-transmembranski receptor za prolaktin-oslobađajući hormon (PRLH; MIM 602663). On je visoko izražen u prednjoj hipofizi.^[3]^[4]

Literatura

^ Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P (1995). „Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors”. Genomics. 29 (2): 335—44. PMID 8666380. doi:10.1006/geno.1995.9996.
^ Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M (1998). „A prolactin-releasing peptide in the brain”. Nature. 393 (6682): 272—6. PMID 9607765. doi:10.1038/30515.
^ Ozawa A; Yamada M; Satoh T; et al. (2002). „Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region”. Molecular Endocrinology (Baltimore, Md.). 16 (4): 785—98. PMID 11923475. |access-date= захтева |url= (помоћ)CS1 одржавање: Експлицитна употреба et al. (веза)
^ „Entrez Gene: PRLHR prolactin releasing hormone receptor”.

Dodatna literatura

Hinuma S, Onda H, Fujino M (1999). „The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors.”. J. Mol. Med. 77 (6): 495—504. PMID 10475064. doi:10.1007/s001090050403.
Marchese A; Heiber M; Nguyen T; et al. (1996). „Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.”. Genomics. 29 (2): 335—44. PMID 8666380. doi:10.1006/geno.1995.9996. CS1 одржавање: Експлицитна употреба et al. (веза)
Hinuma S; Habata Y; Fujii R; et al. (1998). „A prolactin-releasing peptide in the brain.”. Nature. 393 (6682): 272—6. PMID 9607765. doi:10.1038/30515. CS1 одржавање: Експлицитна употреба et al. (веза)
Fujii R; Fukusumi S; Hosoya M; et al. (1999). „Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor.”. Regul. Pept. 83 (1): 1—10. PMID 10498338. doi:10.1016/S0167-0115(99)00028-2. CS1 одржавање: Експлицитна употреба et al. (веза)
Langmead CJ; Szekeres PG; Chambers JK; et al. (2000). „Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor.”. Br. J. Pharmacol. 131 (4): 683—8. PMC 1572376 . PMID 11030716. doi:10.1038/sj.bjp.0703617. CS1 одржавање: Експлицитна употреба et al. (веза)
Lin SH; Arai AC; Wang Z; et al. (2001). „The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.”. Mol. Pharmacol. 60 (5): 916—23. PMID 11641419. CS1 одржавање: Експлицитна употреба et al. (веза)
Takahashi K; Totsune K; Murakami O; et al. (2003). „Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.”. Peptides. 23 (6): 1135—40. PMID 12126742. doi:10.1016/S0196-9781(02)00046-3. CS1 одржавање: Експлицитна употреба et al. (веза)
Kemp DM, Lin JC, Ubeda M, Habener JF (2002). „NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region.”. FEBS Lett. 531 (2): 193—8. PMID 12417311. doi:10.1016/S0014-5793(02)03502-0.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. CS1 одржавање: Експлицитна употреба et al. (веза)
Bhattacharyya S; Luan J; Challis B; et al. (2003). „Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.”. Diabetes. 52 (5): 1296—9. PMID 12716769. doi:10.2337/diabetes.52.5.1296. CS1 одржавање: Експлицитна употреба et al. (веза)
Deloukas P; Earthrowl ME; Grafham DV; et al. (2004). „The DNA sequence and comparative analysis of human chromosome 10.”. Nature. 429 (6990): 375—81. PMID 15164054. doi:10.1038/nature02462. CS1 одржавање: Експлицитна употреба et al. (веза)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. CS1 одржавање: Експлицитна употреба et al. (веза)
Ellacott KL; Donald EL; Clarkson P; et al. (2005). „Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor.”. Peptides. 26 (4): 675—81. PMID 15752583. doi:10.1016/j.peptides.2004.11.020. CS1 одржавање: Експлицитна употреба et al. (веза)
Lagerström MC; Fredriksson R; Bjarnadóttir TK; et al. (2005). „Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution.”. Genomics. 85 (6): 688—703. PMID 15885496. doi:10.1016/j.ygeno.2005.02.007. CS1 одржавање: Експлицитна употреба et al. (веза)
Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55—65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406. CS1 одржавање: Експлицитна употреба et al. (веза)

Spoljašnje veze

„Prolactin-Releasing Peptide Receptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
PRLHR+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)