USP47

Protein-coding gene in the species Homo sapiens
USP47
Identifiers
AliasesUSP47, TRFP, ubiquitin specific peptidase 47
External IDsOMIM: 614460; MGI: 1922246; HomoloGene: 9929; GeneCards: USP47; OMA:USP47 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for USP47
Genomic location for USP47
Band11p15.3Start11,841,423 bp[1]
End11,959,323 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for USP47
Genomic location for USP47
Band7|7 F1Start111,622,711 bp[2]
End111,710,868 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • internal globus pallidus

  • endothelial cell

  • secondary oocyte

  • seminal vesicula

  • vena cava

  • corpus callosum

  • biceps brachii

  • periodontal fiber

  • inferior olivary nucleus

  • Achilles tendon
Top expressed in
  • ciliary body

  • vastus lateralis muscle

  • triceps brachii muscle

  • spermatid

  • gastrocnemius muscle

  • tibialis anterior muscle

  • ankle

  • spermatocyte

  • temporal muscle

  • sternocleidomastoid muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • WD40-repeat domain binding
  • peptidase activity
  • hydrolase activity
  • cysteine-type peptidase activity
  • thiol-dependent deubiquitinase
  • protein binding
  • deubiquitinase activity
  • cysteine-type endopeptidase activity
Cellular component
  • cytoplasm
  • SCF ubiquitin ligase complex
  • nucleoplasm
  • cytosol
Biological process
  • ubiquitin-dependent protein catabolic process
  • proteolysis
  • negative regulation of apoptotic process
  • cellular response to UV
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
  • DNA repair
  • positive regulation of cell growth
  • monoubiquitinated protein deubiquitination
  • base-excision repair
  • negative regulation of G2/M transition of mitotic cell cycle
  • negative regulation of transcription, DNA-templated
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • cellular response to DNA damage stimulus
  • protein deubiquitination
  • positive regulation of canonical Wnt signaling pathway
  • regulation of protein stability
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55031

74996

Ensembl

ENSG00000170242

ENSMUSG00000059263

UniProt

Q96K76

Q8BY87

RefSeq (mRNA)

NM_001282659
NM_017944
NM_001330208

NM_133758
NM_177249
NM_001357952

RefSeq (protein)
NP_001269588
NP_001317137
NP_060414
NP_001359020
NP_001359021

NP_001359022
NP_001359023
NP_001359024
NP_001359025
NP_001359026
NP_001359027
NP_001359028
NP_001359029
NP_001359030
NP_001359031
NP_001359032

NP_598519
NP_796223
NP_001344881
NP_001390423

Location (UCSC)Chr 11: 11.84 – 11.96 MbChr 7: 111.62 – 111.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 47 is an enzyme that in humans is encoded by the USP47 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170242 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059263 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ "Entrez Gene: USP47 ubiquitin specific peptidase 47".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
  • Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
  • Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.


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