TOMM40L

Protein-coding gene in the species Homo sapiens
TOMM40L
Identifiers
AliasesTOMM40L, TOMM40B, translocase of outer mitochondrial membrane 40 like
External IDsMGI: 3589112; HomoloGene: 134180; GeneCards: TOMM40L; OMA:TOMM40L - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TOMM40L
Genomic location for TOMM40L
Band1q23.3Start161,225,939 bp[1]
End161,230,746 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for TOMM40L
Genomic location for TOMM40L
Band1|1 H3Start171,043,580 bp[2]
End171,050,083 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • myocardium of left ventricle

  • apex of heart

  • right lobe of liver

  • prefrontal cortex

  • right auricle

  • right frontal lobe

  • dorsolateral prefrontal cortex

  • anterior cingulate cortex

  • mucosa of transverse colon

  • Brodmann area 9
Top expressed in
  • interventricular septum

  • otic vesicle

  • dentate gyrus of hippocampal formation granule cell

  • saccule

  • superior frontal gyrus

  • muscle of thigh

  • visual cortex

  • motor neuron

  • otic placode

  • extraocular muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • porin activity
  • molecular function
  • protein transmembrane transporter activity
  • mitochondrion targeting sequence binding
  • preprotein binding
Cellular component
  • integral component of membrane
  • mitochondrial outer membrane
  • pore complex
  • mitochondrion
  • membrane
  • mitochondrial outer membrane translocase complex
  • protein-containing complex
Biological process
  • protein transport
  • ion transport
  • transmembrane transport
  • biological process
  • protein import into mitochondrial matrix
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84134

641376

Ensembl

ENSG00000158882

ENSMUSG00000005674

UniProt

Q969M1

Q9CZR3

RefSeq (mRNA)

NM_001286373
NM_001286374
NM_032174

NM_001037170

RefSeq (protein)

NP_001273302
NP_001273303
NP_115550

NP_001032247

Location (UCSC)Chr 1: 161.23 – 161.23 MbChr 1: 171.04 – 171.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial import receptor subunit TOM40B is a protein that in humans is encoded by the TOMM40L gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158882 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005674 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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