TAF7

TAF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RGW, 5FUR
Identifiers
Aliases	TAF7, TAF2F, TAFII55, TATA-box binding protein associated factor 7
External IDs	OMIM: 600573; MGI: 1346348; HomoloGene: 133942; GeneCards: TAF7; OMA:TAF7 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,259,884 bp[1] End 141,320,784 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 37,773,544 bp[2] End 37,777,257 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence Skeletal muscle tissue of biceps brachii islet of Langerhans ventricular zone Skeletal muscle tissue of rectus abdominis gastrocnemius muscle Epithelium of choroid plexus right ventricle vastus lateralis muscle Top expressed in zygote secondary oocyte granulocyte blastocyst morula embryo epiblast Gonadal ridge primary oocyte genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription coactivator activity transcription factor binding thyroid hormone receptor binding protein binding histone acetyltransferase binding vitamin D receptor binding protein heterodimerization activity H3K27me3 modified histone binding TFIIH-class transcription factor complex binding P-TEFb complex binding Cellular component cytoplasm Golgi apparatus transcription factor TFTC complex MLL1 complex cyclin/CDK positive transcription elongation factor complex nucleus nucleoplasm transcription regulator complex transcription factor TFIID complex Biological process regulation of transcription, DNA-templated negative regulation of protein kinase activity regulation of transcription by RNA polymerase II spermine transport RNA polymerase II preinitiation complex assembly negative regulation of transcription by RNA polymerase II transcription, DNA-templated DNA-templated transcription, initiation negative regulation of transcription, DNA-templated negative regulation of histone acetylation intracellular estrogen receptor signaling pathway positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter regulation of transcription initiation from RNA polymerase II promoter regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6879 24074 Ensembl ENSG00000178913 ENSMUSG00000051316 UniProt Q15545 Q9R1C0 RefSeq (mRNA) NM_005642 NM_175770 RefSeq (protein) NP_005633 NP_786964 Location (UCSC) Chr 5: 141.26 – 141.32 Mb Chr 18: 37.77 – 37.78 Mb PubMed search [3] [4]
Wikidata
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Transcription initiation factor TFIID subunit 7 also known as TAFII55 is a protein that in humans is encoded by the TAF7 gene.^[5]

Function

The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II.^[6]

The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. TAFII55 binds to TAFII250 and inhibits its acetyltransferase activity. The exact role of TAFII55 is currently unknown but studies have shown that it interacts with the C-jun pathway.^[7] The conserved region is situated towards the N-terminal of the protein.^[8] This entry talks about the N-terminal domain.

Crystallographic studies have revealed a very significant hydrophobic pocket between TAF7 and TAF1, its main binding partner. Due to the incredible hydrophobicity of this interaction, it is unlikely that TAF1 would be able to fold properly without the presence of TAF7. Thus, it is possible that TAF7 is required for proper production of TAF1^[9]

Interactions

TAF7 has been shown to interact with:

• TAF15,^[10]
• TAF1,^[8] and
• TATA binding protein.^[11][12]

References

Further reading

External links

• FactorBook TAF7
• Overview of all the structural information available in the PDB for UniProt: Q15545 (Transcription initiation factor TFIID subunit 7) at the PDBe-KB.