SULT4A1

Protein-coding gene in the species Homo sapiens
SULT4A1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1ZD1

Identifiers
AliasesSULT4A1, BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1, sulfotransferase family 4A member 1
External IDsOMIM: 608359; MGI: 1888971; HomoloGene: 49378; GeneCards: SULT4A1; OMA:SULT4A1 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for SULT4A1
Genomic location for SULT4A1
Band22q13.31Start43,824,509 bp[1]
End43,862,513 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for SULT4A1
Genomic location for SULT4A1
Band15|15 E2Start83,960,298 bp[2]
End83,989,955 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right frontal lobe

  • prefrontal cortex

  • Brodmann area 9

  • middle temporal gyrus

  • Brodmann area 10

  • right hemisphere of cerebellum

  • primary visual cortex

  • cingulate gyrus

  • anterior cingulate cortex

  • frontal pole
Top expressed in
  • medial dorsal nucleus

  • medial vestibular nucleus

  • superior frontal gyrus

  • medial geniculate nucleus

  • lateral geniculate nucleus

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • deep cerebellar nuclei

  • pontine nuclei

  • primary motor cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • sulfotransferase activity
  • protein binding
  • aryl sulfotransferase activity
  • identical protein binding
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • sulfur compound metabolic process
  • steroid metabolic process
  • 3'-phosphoadenosine 5'-phosphosulfate metabolic process
  • lipid metabolism
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25830

29859

Ensembl

ENSG00000130540

ENSMUSG00000018865

UniProt

Q9BR01

P63046

RefSeq (mRNA)

NM_014351
NM_176874

NM_013873
NM_001356515

RefSeq (protein)

NP_055166

NP_038901
NP_001343444

Location (UCSC)Chr 22: 43.82 – 43.86 MbChr 15: 83.96 – 83.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene.[5][6]

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130540 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018865 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Falany CN, Xie X, Wang J, Ferrer J, Falany JL (May 2000). "Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain". Biochem J. 346. Pt 3 (3): 857–64. doi:10.1042/bj3460857. PMC 1220923. PMID 10698717.
  6. ^ a b "Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1".

Further reading

  • Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160. S2CID 3977677.
  • Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113 (1–3): 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
  • Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. Bibcode:2000CBI...129..141G. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
  • Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Sakakibara Y, Suiko M, Pai TG, et al. (2002). "Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization". Gene. 285 (1–2): 39–47. doi:10.1016/S0378-1119(02)00431-6. PMID 12039030.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
  • Liyou NE, Buller KM, Tresillian MJ, et al. (2004). "Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study". J. Histochem. Cytochem. 51 (12): 1655–64. doi:10.1177/002215540305101209. PMID 14623933.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Brennan MD, Condra J (2006). "Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 139 (1): 69–72. doi:10.1002/ajmg.b.30222. PMID 16152568. S2CID 8927459.
  • Allali-Hassani A, Pan PW, Dombrovski L, et al. (2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840. PMID 17425406.
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  • 1zd1: Human Sulfortransferase SULT4A1
    1zd1: Human Sulfortransferase SULT4A1


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