SULT2B1

Protein-coding gene in the species Homo sapiens

SULT2B1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1Q1Q, 1Q1Z, 1Q20, 1Q22

Identifiers

Aliases

SULT2B1, HSST2, sulfotransferase family 2B member 1, ARCI14

External IDs

OMIM: 604125; MGI: 1926342; HomoloGene: 49487; GeneCards: SULT2B1; OMA:SULT2B1 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.33	Start	48,552,172 bp^[1]
Band	19q13.33	End	48,599,425 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B3	Start	45,379,407 bp^[2]
Band	7\|7 B3	End	45,434,093 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of abdomen

skin of leg

gingival epithelium

skin of arm

mucosa of pharynx

oral cavity

vulva

skin of thigh

epithelium of esophagus

cervix epithelium

Top expressed in

esophagus

jejunum

duodenum

skin of abdomen

skin of external ear

intestinal villus

ileum

skin of back

epidermis

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity sulfotransferase activity protein binding alcohol sulfotransferase activity steroid sulfotransferase activity nucleic acid binding cholesterol binding steroid hormone binding
Cellular component	extracellular exosome endoplasmic reticulum intracellular membrane-bounded organelle nucleus cytoplasm cytosol
Biological process	steroid metabolic process sulfate assimilation lipid metabolism 3'-phosphoadenosine 5'-phosphosulfate metabolic process cholesterol metabolic process negative regulation of cell population proliferation positive regulation of epidermal cell differentiation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6820


54200

Ensembl


ENSG00000088002


ENSMUSG00000003271

UniProt


O00204


O35400

RefSeq (mRNA)


NM_004605 NM_177973


NM_017465 NM_001360784

RefSeq (protein)


NP_004596 NP_814444


NP_059493 NP_001347713

Location (UCSC)

Chr 19: 48.55 – 48.6 Mb

Chr 7: 45.38 – 45.43 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene.^[5]^[6]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic chemical compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088002 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003271 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Her C, Wood TC, Eichler EE, Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM (Dec 1998). "Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene". Genomics. 53 (3): 284–95. doi:10.1006/geno.1998.5518. PMID 9799594.
^ ^a ^b "Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1".

Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160. S2CID 12532583.
Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. Bibcode:2000CBI...129..141G. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
Meloche CA, Falany CN (2001). "Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b)". J. Steroid Biochem. Mol. Biol. 77 (4–5): 261–9. doi:10.1016/S0960-0760(01)00064-4. PMID 11457664. S2CID 20589491.
Geese WJ, Raftogianis RB (2001). "Biochemical characterization and tissue distribution of human SULT2B1". Biochem. Biophys. Res. Commun. 288 (1): 280–9. doi:10.1006/bbrc.2001.5746. PMID 11594786.
Fuda H, Lee YC, Shimizu C, et al. (2002). "Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase". J. Biol. Chem. 277 (39): 36161–6. doi:10.1074/jbc.M207165200. PMID 12145317.
Pai TG, Sugahara T, Suiko M, et al. (2003). "Differential xenoestrogen-sulfating activities of the human cytosolic sulfotransferases: molecular cloning, expression, and purification of human SULT2B1a and SULT2B1b sulfotransferases". Biochim. Biophys. Acta. 1573 (2): 165–70. doi:10.1016/s0304-4165(02)00416-6. PMID 12399026.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lee KA, Fuda H, Lee YC, et al. (2004). "Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms". J. Biol. Chem. 278 (45): 44593–9. doi:10.1074/jbc.M308312200. PMID 12923182.
Yanai H, Javitt NB, Higashi Y, et al. (2004). "Expression of cholesterol sulfotransferase (SULT2B1b) in human platelets". Circulation. 109 (1): 92–6. doi:10.1161/01.CIR.0000108925.95658.8D. PMID 14676143. S2CID 14696645.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
He D, Meloche CA, Dumas NA, et al. (2004). "Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate". Biochem. J. 379 (Pt 3): 533–40. doi:10.1042/BJ20031524. PMC 1224114. PMID 14741047.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Higashi Y, Fuda H, Yanai H, et al. (2004). "Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes". J. Invest. Dermatol. 122 (5): 1207–13. doi:10.1111/j.0022-202X.2004.22416.x. PMID 15140224.

PDB gallery

1q1q: Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP
1q1z: Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of PAP
1q20: Crystal Structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of PAP and pregnenolone
1q22: Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of DHEA and PAP