SLC27A6

Protein-coding gene in the species Homo sapiens
SLC27A6
Identifiers
AliasesSLC27A6, ACSVL2, FACVL2, FATP6, VLCS-H1, solute carrier family 27 member 6
External IDsOMIM: 604196; MGI: 3036230; HomoloGene: 38385; GeneCards: SLC27A6; OMA:SLC27A6 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SLC27A6
Genomic location for SLC27A6
Band5q23.3Start128,538,013 bp[1]
End129,033,642 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for SLC27A6
Genomic location for SLC27A6
Band18|18 D3Start58,689,329 bp[2]
End58,745,845 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • right uterine tube

  • left ventricle

  • right ventricle

  • myocardium

  • hair follicle

  • tibial nerve

  • placenta

  • trigeminal ganglion

  • sural nerve
Top expressed in
  • spermatocyte

  • lower respiratory tract

  • lung

  • lip

  • placenta

  • ovary

  • zone of skin

  • testicle

  • trachea

  • lens
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • long-chain fatty acid-CoA ligase activity
  • nucleotide binding
  • very long-chain fatty acid-CoA ligase activity
  • catalytic activity
  • ligase activity
  • fatty acid transmembrane transporter activity
  • long-chain fatty acid transporter activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • sarcolemma
  • membrane
Biological process
  • metabolism
  • very long-chain fatty acid metabolic process
  • lipid transport
  • fatty acid transport
  • fatty acid metabolic process
  • lipid metabolism
  • long-chain fatty acid transport
  • long-chain fatty acid metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

28965

225579

Ensembl

ENSG00000113396

ENSMUSG00000024600

UniProt

Q9Y2P4

E9Q9W4

RefSeq (mRNA)

NM_001017372
NM_014031
NM_001317984

NM_001081072

RefSeq (protein)

NP_001017372
NP_001304913
NP_054750

NP_001074541

Location (UCSC)Chr 5: 128.54 – 129.03 MbChr 18: 58.69 – 58.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene.[5][6][7]

This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113396 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024600 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, Lodish HF, Stahl A (Apr 2003). "Characterization of a heart-specific fatty acid transport protein". J Biol Chem. 278 (18): 16039–44. doi:10.1074/jbc.M211412200. PMID 12556534.
  6. ^ Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA (Oct 1999). "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein". Mol Genet Metab. 68 (1): 32–42. doi:10.1006/mgme.1999.2883. PMID 10479480.
  7. ^ a b "Entrez Gene: SLC27A6 solute carrier family 27 (fatty acid transporter), member 6".

Further reading

  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Steinberg SJ, Mihalik SJ, Kim DG, et al. (2000). "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J. Biol. Chem. 275 (21): 15605–8. doi:10.1074/jbc.C000015200. PMID 10749848.
  • Watkins PA, Pevsner J, Steinberg SJ (2000). "Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein". Prostaglandins Leukot. Essent. Fatty Acids. 60 (5–6): 323–8. doi:10.1016/S0952-3278(99)80007-6. PMID 10471116.
  • Hirsch D, Stahl A, Lodish HF (1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8625–9. Bibcode:1998PNAS...95.8625H. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.


  • v
  • t
  • e