SLC22A14

SLC22A14
Identifiers
AliasesSLC22A14, OCTL2, OCTL4, ORCTL4, solute carrier family 22 member 14
External IDsOMIM: 604048; MGI: 2685974; HomoloGene: 3530; GeneCards: SLC22A14; OMA:SLC22A14 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SLC22A14
Genomic location for SLC22A14
Band3p22.2Start38,282,294 bp[1]
End38,318,575 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for SLC22A14
Genomic location for SLC22A14
Band9|9 F3Start118,998,523 bp[2]
End119,194,619 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • pancreatic ductal cell

  • lateral nuclear group of thalamus

  • left testis

  • right testis

  • tibialis anterior muscle

  • pars reticulata

  • male germ cell

  • deltoid muscle

  • sperm
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • proximal tubule

  • yolk sac

  • white adipose tissue

  • spleen

  • islet of Langerhans

  • human kidney

  • right kidney
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • organic cation transmembrane transporter activity
  • transmembrane transporter activity
  • inorganic anion exchanger activity
  • sodium-independent organic anion transmembrane transporter activity
Cellular component
  • integral component of membrane
  • integral component of plasma membrane
  • membrane
Biological process
  • organic cation transport
  • transmembrane transport
  • inorganic anion transport
  • sodium-independent organic anion transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9389

382113

Ensembl

ENSG00000144671

ENSMUSG00000070280

UniProt

Q9Y267

Q497L9

RefSeq (mRNA)

NM_004803
NM_001320033

NM_001037749

RefSeq (protein)

NP_001306962
NP_004794

NP_001032838

Location (UCSC)Chr 3: 38.28 – 38.32 MbChr 9: 119 – 119.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 22 member 14 is a protein that in humans is encoded by the SLC22A14 gene.[5]

Function

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144671 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070280 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 22 member 14". Retrieved 2020-01-19.

Further reading

  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.