RNGTT

Protein-coding gene in the species Homo sapiens
RNGTT
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2C46, 3S24

Identifiers
AliasesRNGTT, CAP1A, HCE, HCE1, hCAP, RNA guanylyltransferase and 5'-phosphatase
External IDsOMIM: 603512; MGI: 1329041; HomoloGene: 37851; GeneCards: RNGTT; OMA:RNGTT - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for RNGTT
Genomic location for RNGTT
Band6q15Start88,609,897 bp[1]
End88,963,618 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for RNGTT
Genomic location for RNGTT
Band4|4 A5Start33,310,311 bp[2]
End33,502,614 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cardia

  • nipple

  • pylorus

  • superior surface of tongue

  • mucosa of pharynx

  • ventral tegmental area

  • subthalamic nucleus

  • inferior ganglion of vagus nerve

  • renal medulla

  • trigeminal ganglion
Top expressed in
  • tail of embryo

  • genital tubercle

  • extraocular muscle

  • zygote

  • spermatocyte

  • ventricular zone

  • abdominal wall

  • epiblast

  • embryo

  • thymus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein tyrosine/serine/threonine phosphatase activity
  • phosphatase activity
  • protein tyrosine phosphatase activity
  • polynucleotide 5'-phosphatase activity
  • RNA guanylyltransferase activity
  • triphosphatase activity
  • nucleotidyltransferase activity
  • mRNA guanylyltransferase activity
  • catalytic activity
  • hydrolase activity
  • nucleotide binding
  • GTP binding
  • transferase activity
  • protein binding
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • mRNA processing
  • RNA processing
  • protein dephosphorylation
  • transcription by RNA polymerase II
  • dephosphorylation
  • 7-methylguanosine mRNA capping
  • metabolism
  • peptidyl-tyrosine dephosphorylation
  • polynucleotide 5' dephosphorylation
  • viral process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8732

24018

Ensembl

ENSG00000111880

ENSMUSG00000028274

UniProt

O60942

O55236

RefSeq (mRNA)

NM_001286426
NM_001286428
NM_003800

NM_011884
NM_001305273

RefSeq (protein)

NP_001273355
NP_001273357
NP_003791

NP_001292202
NP_036014

Location (UCSC)Chr 6: 88.61 – 88.96 MbChr 4: 33.31 – 33.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

mRNA-capping enzyme is a protein that in humans is encoded by the RNGTT gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111880 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028274 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (Jan 1999). "Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively". Genomics. 54 (2): 351–3. doi:10.1006/geno.1998.5604. PMID 9828141.
  6. ^ Yamada-Okabe T, Doi R, Shimmi O, Arisawa M, Yamada-Okabe H (May 1998). "Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme". Nucleic Acids Res. 26 (7): 1700–6. doi:10.1093/nar/26.7.1700. PMC 147440. PMID 9512541.
  7. ^ "Entrez Gene: RNGTT RNA guanylyltransferase and 5'-phosphatase".

Further reading

  • Yue Z, Maldonado E, Pillutla R, Cho H, Reinberg D, Shatkin AJ (1998). "Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12898–903. doi:10.1073/pnas.94.24.12898. PMC 24235. PMID 9371772.
  • Tsukamoto T, Shibagaki Y, Murakoshi T, Suzuki M, Nakamura A, Gotoh H, Mizumoto K (1998). "Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme". Biochem. Biophys. Res. Commun. 243 (1): 101–8. doi:10.1006/bbrc.1997.8038. PMID 9473487.
  • Pillutla RC, Yue Z, Maldonado E, Shatkin AJ (1998). "Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes". J. Biol. Chem. 273 (34): 21443–6. doi:10.1074/jbc.273.34.21443. PMID 9705270.
  • Wen Y, Shatkin AJ (1999). "Transcription elongation factor hSPT5 stimulates mRNA capping". Genes Dev. 13 (14): 1774–9. doi:10.1101/gad.13.14.1774. PMC 316881. PMID 10421630.
  • Chiu YL, Coronel E, Ho CK, Shuman S, Rana TM (2001). "HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA". J. Biol. Chem. 276 (16): 12959–66. doi:10.1074/jbc.M007901200. PMID 11278368.
  • Chiu YL, Ho CK, Saha N, Schwer B, Shuman S, Rana TM (2002). "Tat stimulates cotranscriptional capping of HIV mRNA". Mol. Cell. 10 (3): 585–97. doi:10.1016/S1097-2765(02)00630-5. PMID 12408826.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhou M, Deng L, Kashanchi F, Brady JN, Shatkin AJ, Kumar A (2004). "The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 12666–71. doi:10.1073/pnas.1835726100. PMC 240675. PMID 14569024.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human mRNA-capping enzyme (RNGTT)


  • v
  • t
  • e
  • 1i9s: CRYSTAL STRUCTURE OF THE RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME
    1i9s: CRYSTAL STRUCTURE OF THE RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME
  • 1i9t: CRYSTAL STRUCTURE OF THE OXIDIZED RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME
    1i9t: CRYSTAL STRUCTURE OF THE OXIDIZED RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME
  • 2c46: CRYSTAL STRUCTURE OF THE HUMAN RNA GUANYLYLTRANSFERASE AND 5'-PHOSPHATASE
    2c46: CRYSTAL STRUCTURE OF THE HUMAN RNA GUANYLYLTRANSFERASE AND 5'-PHOSPHATASE
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Class I
Classical PTPs
Receptor type PTPs
Non receptor type PTPs
VH1-like or
dual specific
phosphatases
(DSPs)
MAPK phosphatases (MKPs)
Slingshots
PRLs
CDC14s
Atypical DSPs
Phosphatase and tensin
homologs (PTENs)
Myotubularins
Class II
Class III
Class IV


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