Phosphomevalonate kinase

Protein-coding gene in the species Homo sapiens

PMVK

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3CH4

Identifiers

Aliases

PMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1, phosphomevalonate kinase

External IDs

OMIM: 607622 MGI: 1915853 HomoloGene: 4779 GeneCards: PMVK

EC number

2.7.4.2

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q21.3	Start	154,924,740 bp^[1]
Band	1q21.3	End	154,936,719 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F1	Start	89,361,848 bp^[2]
Band	3\|3 F1	End	89,376,320 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lobe of liver

anterior pituitary

nucleus accumbens

skin of abdomen

caudate nucleus

amygdala

left adrenal gland

prefrontal cortex

putamen

Brodmann area 9

Top expressed in

fossa

condyle

motor neuron

facial motor nucleus

trigeminal ganglion

ectoderm

otic placode

supraoptic nucleus

left lobe of liver

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity nucleotide binding ATP binding kinase activity phosphomevalonate kinase activity
Cellular component	cytoplasm cytosol peroxisome extracellular exosome membrane
Biological process	cholesterol biosynthetic process steroid metabolic process isopentenyl diphosphate biosynthetic process, mevalonate pathway response to cholesterol cholesterol metabolic process sterol biosynthetic process isoprenoid biosynthetic process phosphorylation lipid metabolism steroid biosynthetic process regulation of cholesterol biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10654


68603

Ensembl


ENSG00000163344


ENSMUSG00000027952

UniProt


Q15126


Q9D1G2

RefSeq (mRNA)


NM_006556 NM_001323011 NM_001323012 NM_001348696


NM_026784 NM_027348 NM_001310640

RefSeq (protein)


NP_001309940 NP_001309941 NP_006547 NP_001335625


NP_001297569 NP_081060 NP_081624

Location (UCSC)

Chr 1: 154.92 – 154.94 Mb

Chr 3: 89.36 – 89.38 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphomevalonate kinase

Identifiers

EC no.

2.7.4.2

CAS no.

9026-46-4

Databases

IntEnz view

BRENDA entry

NiceZyme view

KEGG entry

metabolic pathway

profile

PDB structures

RCSB PDB PDBe PDBsum

Search
PMC	articles
PubMed	articles
NCBI	proteins

Phosphomevalonate kinase

Identifiers

Symbol

PMVK

10654

9141

607622

NM_006556

Q15126

Other data

EC number

2.7.4.2

Locus

Chr. 1 p13-q23

Search for
Structures	Swiss-model
Domains	InterPro

Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway^[5]^[6]^[7] that in humans is encoded by the PMVK gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163344 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027952 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234 (10): 2595–604. doi:10.1016/S0021-9258(18)69744-3. PMID 13801508.
^ Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.
^ Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75 (3): 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.

External links

Phosphomevalonate+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q15126 (Phosphomevalonate kinase) at the PDBe-KB.

Metabolism: lipid metabolism – ketones/cholesterol synthesis enzymes/steroid metabolism

Mevalonate pathway

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase HMG-CoA synthase (regulated step)
Ketogenesis	HMG-CoA lyase 3-hydroxybutyrate dehydrogenase Thiophorase
To Mevalonic acid	HMG-CoA reductase
To DMAPP	Mevalonate kinase Phosphomevalonate kinase Pyrophosphomevalonate decarboxylase Isopentenyl-diphosphate delta isomerase
Geranyl-	Dimethylallyltranstransferase Geranyl pyrophosphate

To cholesterol

To lanosterol	Farnesyl-diphosphate farnesyltransferase Squalene monooxygenase Lanosterol synthase
7-Dehydrocholesterol path	Lanosterol 14α-demethylase Sterol-C5-desaturase-like 7-Dehydrocholesterol reductase
Desmosterol path	24-Dehydrocholesterol reductase

To Bile acids

Steroidogenesis

To pregnenolone

Cholesterol side-chain cleavage

To corticosteroids

aldosterone: 18-Hydroxylase

cortisol/cortisone: 17α-Hydroxylase
11β-HSD
- 1
- 2

both: 3β-HSD
- 1
- 2
21-Hydroxylase
11β-Hydroxylase

To sex hormones

To androgens	17α-Hydroxylase 17,20-Lyase 3β-HSD 17β-HSD 5α-Reductase 1 2
To estrogens	Aromatase 17β-HSD

Other/ungrouped

Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor	Hexo- Gluco- Fructo- Hepatic Galacto- Phosphofructo- 1 Liver Muscle Platelet 2 Riboflavin Shikimate Thymidine ADP-thymidine NAD⁺ Glycerol Pantothenate Mevalonate Pyruvate Deoxycytidine PFP Diacylglycerol Phosphoinositide 3 Class I PI 3 Class II PI 3 Sphingosine Glucose-1,6-bisphosphate synthase
2.7.2: COOH acceptor	Phosphoglycerate Aspartate kinase
2.7.3: N acceptor	Creatine
2.7.4: PO₄ acceptor	Phosphomevalonate Adenylate Nucleoside-diphosphate Uridylate Guanylate Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase	DNA-directed DNA polymerase I/A γ θ ν T7 Taq II/B α δ ε ζ Pfu III/C IV/X β λ μ TDT V/Y η ι κ RNA-directed DNA polymerase Reverse transcriptase Telomerase
RNA polymerase	Template-directed RNA polymerase I II III IV V ssRNAP POLRMT Primase 1 2 PrimPol RNA-dependent RNA polymerase Polyadenylation PAP PNPase

Phosphorolytic
3' to 5' exoribonuclease

Nucleotidyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

2.7.8: miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase CDP-diacylglycerol—serine O-phosphatidyltransferase CDP-diacylglycerol—inositol 3-phosphatidyltransferase CDP-diacylglycerol—choline O-phosphatidyltransferase
Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine	see tyrosine kinases
2.7.11: protein-serine/threonine	see serine/threonine-specific protein kinases
2.7.12: protein-dual-specificity	see serine/threonine-specific protein kinases
2.7.13: protein-histidine	Protein-histidine pros-kinase Protein-histidine tele-kinase Histidine kinase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)