PFKFB1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | PFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 |
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External IDs | OMIM: 311790; MGI: 107816; HomoloGene: 105654; GeneCards: PFKFB1; OMA:PFKFB1 - orthologs |
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Gene location (Human) |
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| Chr. | X chromosome (human)[1] |
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| Band | Xp11.21 | Start | 54,932,961 bp[1] |
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End | 54,998,534 bp[1] |
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Gene location (Mouse) |
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| Chr. | X chromosome (mouse)[2] |
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| Band | X|X F3 | Start | 149,371,225 bp[2] |
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End | 149,426,874 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right lobe of liver
- gastrocnemius muscle
- vastus lateralis muscle
- biceps brachii
- triceps brachii muscle
- deltoid muscle
- adipose tissue
- subcutaneous adipose tissue
- abdominal fat
- tibialis anterior muscle
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| Top expressed in | - sternocleidomastoid muscle
- vastus lateralis muscle
- triceps brachii muscle
- masseter muscle
- tibialis anterior muscle
- temporal muscle
- digastric muscle
- gastrocnemius muscle
- right ventricle
- plantaris muscle
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - transferase activity
- nucleotide binding
- fructose-6-phosphate binding
- kinase activity
- catalytic activity
- protein binding
- identical protein binding
- fructose-2,6-bisphosphate 2-phosphatase activity
- hydrolase activity
- ATP binding
- 6-phosphofructo-2-kinase activity
- kinase binding
| Cellular component | - cytosol
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
| Biological process | - gluconeogenesis
- response to glucagon
- glycolytic process
- phosphorylation
- fructose metabolic process
- response to glucocorticoid
- carbohydrate phosphorylation
- response to insulin
- positive regulation of glucokinase activity
- fructose 2,6-bisphosphate metabolic process
- animal organ regeneration
- response to starvation
- metabolism
- response to cAMP
- dephosphorylation
- negative regulation of glycolytic process
- positive regulation of glycolytic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001271804 NM_001271805 NM_002625 |
| NM_008824 NM_001374170 NM_001374171 NM_001374172 NM_001374173
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NM_001374175 |
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RefSeq (protein) | |
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NP_001258733 NP_001258734 NP_002616 |
| NP_032850 NP_001361099 NP_001361100 NP_001361101 NP_001361102
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NP_001361104 |
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Location (UCSC) | Chr X: 54.93 – 55 Mb | Chr X: 149.37 – 149.43 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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