Protein-coding gene in the species Homo sapiens
| SLC51A |
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| Identifiers |
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| Aliases | SLC51A, OSTA, OSTalpha, solute carrier family 51 alpha subunit, solute carrier family 51 subunit alpha, PFIC6 |
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| External IDs | OMIM: 612084; MGI: 2146634; HomoloGene: 44941; GeneCards: SLC51A; OMA:SLC51A - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 3 (human)[1] |
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| | Band | 3q29 | Start | 196,211,487 bp[1] |
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| End | 196,243,178 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 16 (mouse)[2] |
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| | Band | 16|16 B3 | Start | 32,293,322 bp[2] |
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| End | 32,306,697 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - mucosa of ileum
- mucosa of transverse colon
- right lobe of liver
- nasal epithelium
- jejunal mucosa
- duodenum
- olfactory zone of nasal mucosa
- right testis
- sperm
- left testis
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| | Top expressed in | - ileum
- intestinal villus
- jejunum
- right kidney
- duodenum
- Ileal epithelium
- human kidney
- migratory enteric neural crest cell
- proximal tubule
- crypt of lieberkuhn of small intestine
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - protein homodimerization activity
- protein heterodimerization activity
- bile acid transmembrane transporter activity
- transmembrane transporter activity
| | Cellular component | - integral component of membrane
- plasma membrane
- endoplasmic reticulum membrane
- endoplasmic reticulum
- membrane
- basolateral plasma membrane
- protein-containing complex
| | Biological process | - bile acid and bile salt transport
- bile acid secretion
- transmembrane transport
- organic substance transport
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 3: 196.21 – 196.24 Mb | Chr 16: 32.29 – 32.31 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the SLC51A gene.[5][6]
Function
OST-alpha together with OST-beta is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[6][7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[7] The heterodimer furthermore is essential for intestinal bile acid transport.[8]
OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[6]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163959 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035699 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: OSTalpha organic solute transporter alpha".
- ^ a b c Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432.
- ^ a b Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727. PMID 15563450.
- ^ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. Bibcode:2008PNAS..105.3891R. doi:10.1073/pnas.0712328105. PMC 2268840. PMID 18292224.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Seward DJ, Koh AS, Boyer JL, Ballatori N (2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432.
- Dawson PA, Hubbert M, Haywood J, et al. (2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727. PMID 15563450.
- Lee H, Zhang Y, Lee FY, et al. (2006). "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine". J. Lipid Res. 47 (1): 201–14. doi:10.1194/jlr.M500417-JLR200. PMID 16251721.
- Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA (2006). "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G476–85. doi:10.1152/ajpgi.00430.2005. PMID 16269519. S2CID 8687386.
- Ballatori N, Christian WV, Lee JY, et al. (2005). "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia". Hepatology. 42 (6): 1270–9. doi:10.1002/hep.20961. PMID 16317684. S2CID 55829915.
- Boyer JL, Trauner M, Mennone A, et al. (2006). "Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (6): G1124–30. doi:10.1152/ajpgi.00539.2005. PMID 16423920. S2CID 86156271.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
- Sun AQ, Balasubramaniyan N, Xu K, et al. (2007). "Protein-protein interactions and membrane localization of the human organic solute transporter". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (6): G1586–93. doi:10.1152/ajpgi.00457.2006. PMID 17332473.
