KRT33A

Protein-coding gene in the species Homo sapiens
KRT33A
Identifiers
AliasesKRT33A, HA3I, Ha-3I, K33A, KRTHA3A, Krt1-3, hHa3-I, keratin 33A
External IDsOMIM: 602761; MGI: 1919138; HomoloGene: 135742; GeneCards: KRT33A; OMA:KRT33A - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for KRT33A
Genomic location for KRT33A
Band17q21.2Start41,346,092 bp[1]
End41,350,828 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for KRT33A
Genomic location for KRT33A
Band11|11 DStart99,902,021 bp[2]
End99,907,038 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • mucosa of esophagus

  • left testis

  • right testis

  • skin of abdomen

  • vagina

  • skin of leg

  • minor salivary glands

  • right lung

  • ectocervix
Top expressed in
  • lip

  • hair follicle

  • skin of back

  • dermis

  • skin of external ear

  • skin of abdomen

  • sexually immature organism

  • medial head of gastrocnemius muscle

  • conjunctival fornix

  • diencephalon
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural molecule activity
Cellular component
  • intermediate filament
  • extracellular space
  • cytosol
Biological process
  • keratinization
  • cornification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3883

71888

Ensembl

ENSG00000261986
ENSG00000006059

ENSMUSG00000035592

UniProt

O76009

Q8K0Y2

RefSeq (mRNA)

NM_004138

NM_027983

RefSeq (protein)

NP_004129

NP_082259

Location (UCSC)Chr 17: 41.35 – 41.35 MbChr 11: 99.9 – 99.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.[5][6][7]

The protein encoded by this gene is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, KRTHA3A and KRTHA3B.[7]

References

  1. ^ a b c ENSG00000006059 GRCh38: Ensembl release 89: ENSG00000261986, ENSG00000006059 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035592 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rogers MA, Schweizer J, Kreig T, Winter H (Nov 1995). "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms". Mol Biol Rep. 20 (3): 155–61. doi:10.1007/BF00990548. PMID 7565656. S2CID 24487602.
  6. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  7. ^ a b "Entrez Gene: KRT33A keratin 33A".

Further reading

  • Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635 (inactive 2024-04-03). PMID 7686952.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Rogers MA, Winter H, Langbein L, et al. (2005). "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain". Differentiation. 72 (9–10): 527–40. doi:10.1111/j.1432-0436.2004.07209006.x. PMID 15617563.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
  • Rogers MA, Winter H, Wolf C, et al. (1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J. Biol. Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
  • v
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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