IPO11

Protein-coding gene in the species Homo sapiens
IPO11
Identifiers
AliasesIPO11, RanBP11, importin 11
External IDsOMIM: 610889; MGI: 2442377; HomoloGene: 7089; GeneCards: IPO11; OMA:IPO11 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for IPO11
Genomic location for IPO11
Band5q12.1Start62,403,972 bp[1]
End62,628,582 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for IPO11
Genomic location for IPO11
Band13|13 D1- D2.1Start106,930,947 bp[2]
End107,073,466 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • testicle

  • epithelium of colon

  • bronchial epithelial cell

  • ventricular zone

  • right testis

  • left testis

  • sperm

  • Achilles tendon

  • olfactory zone of nasal mucosa
Top expressed in
  • tail of embryo

  • genital tubercle

  • blood

  • primitive streak

  • somite

  • spermatocyte

  • ventricular zone

  • utricle

  • epiblast

  • cumulus cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • nuclear import signal receptor activity
Cellular component
  • cytoplasm
  • fibrillar center
  • nucleus
  • nuclear envelope
  • cytosol
Biological process
  • protein transport
  • intracellular protein transport
  • ribosomal protein import into nucleus
  • protein import into nucleus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51194

76582

Ensembl

ENSG00000086200

ENSMUSG00000042590

UniProt

Q9UI26

Q8K2V6

RefSeq (mRNA)

NM_016338
NM_001134779

NM_029665
NM_001360897
NM_175202

RefSeq (protein)

NP_001128251
NP_057422

NP_083941
NP_001347826

Location (UCSC)Chr 5: 62.4 – 62.63 MbChr 13: 106.93 – 107.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Importin-11 is a protein that in humans is encoded by the IPO11 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000086200 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042590 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: IPO11 importin 11".

Further reading

  • Plafker SM, Macara IG (2000). "Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2". EMBO J. 19 (20): 5502–13. doi:10.1093/emboj/19.20.5502. PMC 314000. PMID 11032817.
  • Plafker SM, Macara IG (2002). "Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11". Mol. Cell. Biol. 22 (4): 1266–75. doi:10.1128/MCB.22.4.1266-1275.2002. PMC 134630. PMID 11809816.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wang W, Yang Y, Li L, Shi Y (2003). "Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses". Biochem. Biophys. Res. Commun. 305 (4): 981–8. doi:10.1016/S0006-291X(03)00876-3. PMID 12767927.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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