HTR3C

Protein-coding gene in the species Homo sapiens
HTR3C
Identifiers
AliasesHTR3C, 5-hydroxytryptamine receptor 3C
External IDsOMIM: 610121; HomoloGene: 50847; GeneCards: HTR3C; OMA:HTR3C - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for HTR3C
Genomic location for HTR3C
Band3q27.1Start184,053,047 bp[1]
End184,060,673 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • right lung

  • mucosa of transverse colon

  • upper lobe of left lung

  • duodenum

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • gallbladder

  • myometrium

  • skin of abdomen
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • extracellular ligand-gated ion channel activity
  • serotonin-gated cation-selective channel activity
  • ion channel activity
  • transmembrane signaling receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
  • neuron projection
  • synapse
Biological process
  • ion transport
  • signal transduction
  • ion transmembrane transport
  • serotonin receptor signaling pathway
  • chemical synaptic transmission
  • regulation of membrane potential
  • nervous system process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

170572

n/a

Ensembl

ENSG00000178084

n/a

UniProt

Q8WXA8

n/a

RefSeq (mRNA)

NM_130770

n/a

RefSeq (protein)

NP_570126

n/a

Location (UCSC)Chr 3: 184.05 – 184.06 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

5-hydroxytryptamine receptor 3C is a protein that in humans is encoded by the HTR3C gene.[3][4] The protein encoded by this gene is a subunit of the 5-HT3 receptor.[4]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178084 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Niesler B, Frank B, Kapeller J, Rappold GA (Jun 2003). "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E". Gene. 310: 101–11. doi:10.1016/S0378-1119(03)00503-1. PMID 12801637.
  4. ^ a b Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ (May 2004). "The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance". Biochem Soc Trans. 32 (Pt3): 547–52. doi:10.1042/BST0320547. PMID 15157181.

Further reading

  • Karnovsky AM, Gotow LF, McKinley DD, et al. (2003). "A cluster of novel serotonin receptor 3-like genes on human chromosome 3". Gene. 319: 137–48. doi:10.1016/S0378-1119(03)00803-5. PMID 14597179.
  • Fasching PA, Kollmannsberger B, Strissel PL, et al. (2008). "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy". J. Cancer Res. Clin. Oncol. 134 (10): 1079–86. doi:10.1007/s00432-008-0387-1. PMID 18389280. S2CID 7504731.
  • Ward MB, Kotasek D, McKinnon RA (2008). "Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy". Pharmacogenomics. 9 (8): 1027–33. doi:10.2217/14622416.9.8.1027. PMID 18681779.

External links

  • v
  • t
  • e
Cys-loop receptors
5-HT/serotonin
GABA
  • GABAA
    • α1
    • α2
    • α3
    • α4
    • α5
    • α6
    • β1
    • β2
    • β3
    • γ1
    • γ2
    • γ3
    • δ
    • ε
    • π
    • θ
  • GABAA-ρ
    • ρ1
    • ρ2
    • ρ3
Glycine
  • α1
  • α2
  • α3
  • α4
  • β
Nicotinic acetylcholine
  • pentamers: (α3)2(β4)3
  • (α4)2(β2)3
  • (α7)5
  • (α1)2(β4)3 - Ganglion type
  • (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
Ligand-gated only
Voltage- and ligand-gated
‘Orphan’
  • GluD
    • δ1
    • δ2
ATP-gated channels
Purinergic receptors


Stub icon

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e