HS3ST3B1

Protein-coding gene in the species Homo sapiens
HS3ST3B1
Identifiers
AliasesHS3ST3B1, 30ST3B1, 3OST3B1, 3-OST-3B, h3-OST-3B, heparan sulfate-glucosamine 3-sulfotransferase 3B1
External IDsOMIM: 604058; MGI: 1333853; HomoloGene: 88576; GeneCards: HS3ST3B1; OMA:HS3ST3B1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for HS3ST3B1
Genomic location for HS3ST3B1
Band17p12Start14,301,081 bp[1]
End14,349,404 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for HS3ST3B1
Genomic location for HS3ST3B1
Band11 B3|11 39.47 cMStart63,776,618 bp[2]
End63,813,116 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • parotid gland

  • epithelium of nasopharynx

  • right lobe of liver

  • palpebral conjunctiva

  • placenta

  • cartilage tissue

  • gingival epithelium

  • germinal epithelium

  • stromal cell of endometrium
Top expressed in
  • epithelium of stomach

  • left lobe of liver

  • renal corpuscle

  • female external genitalia

  • paramesonephric duct

  • retinal pigment epithelium

  • ciliary body

  • neural layer of retina

  • cornea

  • abdominal wall
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • sulfotransferase activity
  • [heparan sulfate-glucosamine 3-sulfotransferase 3 activity]
  • [heparan sulfate-glucosamine 3-sulfotransferase 1 activity]
  • heparan sulfate sulfotransferase activity
Cellular component
  • integral component of membrane
  • Golgi membrane
  • Golgi apparatus
  • integral component of plasma membrane
  • membrane
Biological process
  • heparan sulfate proteoglycan biosynthetic process
  • heparan sulfate proteoglycan biosynthetic process, enzymatic modification
  • glycosaminoglycan biosynthetic process
  • protein sulfation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9953

54710

Ensembl

ENSG00000125430

ENSMUSG00000070407

UniProt

Q9Y662

Q9QZS6

RefSeq (mRNA)

NM_006041

NM_018805

RefSeq (protein)

NP_006032

NP_061275

Location (UCSC)Chr 17: 14.3 – 14.35 MbChr 11: 63.78 – 63.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene.[5][6] Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125430 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070407 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (Mar 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J Biol Chem. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.
  6. ^ a b "Entrez Gene: HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1".

Further reading

  • Razi N, Lindahl U (1995). "Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides". J. Biol. Chem. 270 (19): 11267–75. doi:10.1074/jbc.270.19.11267. PMID 7744762.
  • Liu J, Shworak NW, Sinaÿ P, et al. (1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities". J. Biol. Chem. 274 (8): 5185–92. doi:10.1074/jbc.274.8.5185. PMID 9988768.
  • Shukla D, Liu J, Blaiklock P, et al. (1999). "A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry". Cell. 99 (1): 13–22. doi:10.1016/S0092-8674(00)80058-6. PMID 10520990. S2CID 14139940.
  • Salehi LB, Mangino M, De Serio S, et al. (2002). "Assignment of a locus for autosomal dominant idiopathic scoliosis (IS) to human chromosome 17p11". Hum. Genet. 111 (4–5): 401–4. doi:10.1007/s00439-002-0785-4. PMID 12384783. S2CID 29912776.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Moon AF, Edavettal SC, Krahn JM, et al. (2004). "Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1". J. Biol. Chem. 279 (43): 45185–93. doi:10.1074/jbc.M405013200. PMC 4114238. PMID 15304505.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • v
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  • 1t8t: Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP
    1t8t: Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP
  • 1t8u: Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP and tetrasaccharide substrate
    1t8u: Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP and tetrasaccharide substrate


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