HS3ST1

Protein-coding gene in the species Homo sapiens
HS3ST1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1ZRH

Identifiers
AliasesHS3ST1, 3OST, 3OST1, heparan sulfate-glucosamine 3-sulfotransferase 1
External IDsOMIM: 603244; MGI: 1201606; HomoloGene: 3751; GeneCards: HS3ST1; OMA:HS3ST1 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for HS3ST1
Genomic location for HS3ST1
Band4p15.33Start11,393,150 bp[1]
End11,429,564 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for HS3ST1
Genomic location for HS3ST1
Band5 B3|5 21.14 cMStart39,771,278 bp[2]
End39,912,818 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nasal epithelium

  • bronchial epithelial cell

  • mucosa of paranasal sinus

  • left ovary

  • caput epididymis

  • oral cavity

  • buccal mucosa cell

  • right ovary

  • palpebral conjunctiva

  • epithelium of nasopharynx
Top expressed in
  • cerebellar cortex

  • cumulus cell

  • lobe of cerebellum

  • olfactory bulb

  • dentate gyrus of hippocampal formation granule cell

  • gray matter layer of cerebellum

  • cerebellar vermis

  • primary visual cortex

  • ventricular zone

  • barrel cortex
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • sulfotransferase activity
  • [heparan sulfate-glucosamine 3-sulfotransferase 1 activity]
  • heparan sulfate sulfotransferase activity
Cellular component
  • Golgi lumen
  • integral component of membrane
  • Golgi apparatus
Biological process
  • glycosaminoglycan biosynthetic process
  • heparan sulfate proteoglycan biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9957

15476

Ensembl

ENSG00000002587

ENSMUSG00000051022

UniProt

O14792

O35310

RefSeq (mRNA)

NM_005114

NM_010474

RefSeq (protein)

NP_005105

NP_034604

Location (UCSC)Chr 4: 11.39 – 11.43 MbChr 5: 39.77 – 39.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.[5][6]

Function

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.[6]

Clinical significance

Polymorphisms in HS3ST1 appear to be a risk factor for developing Alzheimer's disease.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000002587 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051022 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (February 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". The Journal of Biological Chemistry. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.
  6. ^ a b "Entrez Gene: HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1".
  7. ^ Witoelar A, Rongve A, Almdahl IS, et al. (2018-12-27). "Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci". Scientific Reports. 8 (1): 18088. Bibcode:2018NatSR...818088W. doi:10.1038/s41598-018-36429-6. PMC 6308232. PMID 30591712.

Further reading

  • Razi N, Lindahl U (May 1995). "Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides". The Journal of Biological Chemistry. 270 (19): 11267–75. doi:10.1074/jbc.270.19.11267. PMID 7744762.
  • Liu J, Shworak NW, Fritze LM, Edelberg JM, Rosenberg RD (October 1996). "Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase". The Journal of Biological Chemistry. 271 (43): 27072–82. doi:10.1074/jbc.271.43.27072. PMID 8900198.
  • Shworak NW, Liu J, Fritze LM, Schwartz JJ, Zhang L, Logeart D, Rosenberg RD (October 1997). "Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase". The Journal of Biological Chemistry. 272 (44): 28008–19. doi:10.1074/jbc.272.44.28008. PMID 9346953.
  • Liu J, Shworak NW, Sinaÿ P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD (February 1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities". The Journal of Biological Chemistry. 274 (8): 5185–92. doi:10.1074/jbc.274.8.5185. PMID 9988768.
  • Hernaiz M, Liu J, Rosenberg RD, Linhardt RJ (September 2000). "Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III". Biochemical and Biophysical Research Communications. 276 (1): 292–7. doi:10.1006/bbrc.2000.3453. PMID 11006120.
  • Edavettal SC, Carrick K, Shah RR, Pedersen LC, Tropsha A, Pope RM, Liu J (April 2004). "A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate". Biochemistry. 43 (16): 4680–8. doi:10.1021/bi0499112. PMID 15096036.

External links

  • Overview of all the structural information available in the PDB for UniProt: O14792 (Human Heparan sulfate glucosamine 3-O-sulfotransferase 1) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: O35310 (Mouse Heparan sulfate glucosamine 3-O-sulfotransferase 1) at the PDBe-KB.
  • v
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  • e
  • 1vkj: Crystal structure of heparan sulfate 3-O-sulfotransferase isoform 1 in the presence of PAP
    1vkj: Crystal structure of heparan sulfate 3-O-sulfotransferase isoform 1 in the presence of PAP
  • 1zrh: Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP
    1zrh: Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP


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