Flavokavain A
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| Names | |
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| Preferred IUPAC name 2′-Hydroxy-4,4′,6′-trimethoxychalcone | |
| Other names Flavokawain A | |
| Identifiers | |
CAS Number |
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3D model (JSmol) |
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Beilstein Reference | 2224776 |
PubChem CID |
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| UNII |
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CompTox Dashboard (EPA) |
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| Properties | |
Chemical formula | C18H18O5 |
| Molar mass | 314.337 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).  Y verify (what is  Y N ?) Infobox references | |
Chemical compound
Flavokavain A is a flavokavain found in the kava plant.[1] It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway.[2]
Flavokavains A and B enhance hepatotoxicity of paracetamol, underscoring a potentially serious interaction between paracetamol and kava.
See also
- Kavalactone
References
- ^ Dharmaratne, H. Ranjith W.; N. P. Dhammika Nanayakkara; Ikhlas A. Khan (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry. 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162.
- ^ Zi X, Simoneau AR (April 2005). "Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice" (PDF). Cancer Research. 65 (8): 3479–86. doi:10.1158/0008-5472.CAN-04-3803. PMID 15833884.
External links
- Flavokawain A at the United States National Library of Medicine
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Kava
- Kava
- Kava culture
- Coconut shell cup
| Kavalactones | |
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| Flavokavains |
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