FUT9

Protein-coding gene in the species Homo sapiens
FUT9
Identifiers
AliasesFUT9, Fuc-TIX, fucosyltransferase 9
External IDsOMIM: 606865; MGI: 1330859; HomoloGene: 4800; GeneCards: FUT9; OMA:FUT9 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for FUT9
Genomic location for FUT9
Band6q16.1Start96,015,974 bp[1]
End96,215,612 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for FUT9
Genomic location for FUT9
Band4 A3|4 10.59 cMStart25,609,332 bp[2]
End25,800,244 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pylorus

  • cerebellar vermis

  • Brodmann area 46

  • endothelial cell

  • orbitofrontal cortex

  • postcentral gyrus

  • Brodmann area 23

  • middle temporal gyrus

  • entorhinal cortex

  • pars reticulata
Top expressed in
  • lobe of cerebellum

  • cerebellar vermis

  • lateral geniculate nucleus

  • medial geniculate nucleus

  • dorsal tegmental nucleus

  • medial dorsal nucleus

  • lateral hypothalamus

  • medial vestibular nucleus

  • deep cerebellar nuclei

  • globus pallidus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • glycosyltransferase activity
  • alpha-(1->3)-fucosyltransferase activity
  • fucosyltransferase activity
  • transferase activity
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • Golgi cisterna membrane
  • membrane
  • Golgi membrane
Biological process
  • L-fucose catabolic process
  • fucosylation
  • nervous system development
  • protein glycosylation
  • carbohydrate metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10690

14348

Ensembl

ENSG00000172461

ENSMUSG00000055373

UniProt

Q9Y231

O88819

RefSeq (mRNA)

NM_006581

NM_010243

RefSeq (protein)

NP_006572

NP_034373

Location (UCSC)Chr 6: 96.02 – 96.22 MbChr 4: 25.61 – 25.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT9 gene.[5][6][7]

FUT9 is one of several alpha-3-fucosyltransferases that can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides. FUT9 synthesizes the LeX oligosaccharide (CD15), which is expressed in organ buds progressing in mesenchyma during human embryogenesis.[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172461 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055373 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kaneko M, Kudo T, Iwasaki H, Ikehara Y, Nishihara S, Nakagawa S, Sasaki K, Shiina T, Inoko H, Saitou N, Narimatsu H (Jul 1999). "Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX". FEBS Lett. 452 (3): 237–42. doi:10.1016/S0014-5793(99)00640-7. PMID 10386598. S2CID 21861521.
  6. ^ Kaneko M, Kudo T, Iwasaki H, Shiina T, Inoko H, Kozaki T, Saitou N, Narimatsu H (Jan 2000). "Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization". Cytogenet Cell Genet. 86 (3–4): 329–30. doi:10.1159/000015329. PMID 10575236. S2CID 85080516.
  7. ^ a b "Entrez Gene: FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nishihara S, Iwasaki H, Kaneko M, et al. (2000). "Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue". FEBS Lett. 462 (3): 289–94. doi:10.1016/S0014-5793(99)01549-5. PMID 10622713. S2CID 37842289.
  • Cailleau-Thomas A, Coullin P, Candelier JJ, et al. (2000). "FUT4 and FUT9 genes are expressed early in human embryogenesis". Glycobiology. 10 (8): 789–802. doi:10.1093/glycob/10.8.789. PMID 10929005.
  • Nakayama F, Nishihara S, Iwasaki H, et al. (2001). "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV". J. Biol. Chem. 276 (19): 16100–6. doi:10.1074/jbc.M007272200. PMID 11278338.
  • Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
  • Toivonen S, Nishihara S, Narimatsu H, et al. (2003). "Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile". Glycobiology. 12 (6): 361–8. doi:10.1093/glycob/12.6.361. PMID 12107078.
  • Li H, Kong Y, Yan B (2003). "[Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (6): 775–9. PMID 12417923.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nishihara S, Iwasaki H, Nakajima K, et al. (2004). "Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain". Glycobiology. 13 (6): 445–55. doi:10.1093/glycob/cwg048. PMID 12626397.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Bogoevska V, Horst A, Klampe B, et al. (2006). "CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues". Glycobiology. 16 (3): 197–209. doi:10.1093/glycob/cwj057. PMID 16282604.
  • v
  • t
  • e
2.4.1: Hexosyl-
transferases
Glucosyl-
Galactosyl-
Glucuronosyl-
Fucosyl-
Mannosyl-
2.4.2: Pentosyl-
transferases
Ribose
ADP-ribosyltransferase
Phosphoribosyltransferase
Other
Other
2.4.99: Sialyl
transferases


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