Dyclonine

Anesthetic

N01BX02 (WHO) R02AD04 (WHO)

Legal statusLegal status

US: OTC

Identifiers

IUPAC name

1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one

CAS Number

586-60-7^Y

PubChem CID

3180

IUPHAR/BPS

7173

DrugBank

DB00645^Y

ChemSpider

3068^Y

UNII

078A24Q30O

KEGG

D07881^Y

ChEBI

CHEBI:4724^Y

ChEMBL

ChEMBL1201217^N

CompTox Dashboard (EPA)

DTXSID6047864

Chemical and physical dataFormulaC₁₈H₂₇NO₂Molar mass289.419 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2

InChI

InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3^Y
Key:BZEWSEKUUPWQDQ-UHFFFAOYSA-N^Y

^NY (what is this?) (verify)

Dyclonine (Dyclocaine) is an oral anaesthetic that is the active ingredient of Sucrets, an over-the-counter throat lozenge.^[1] It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.^[2]

History

The product Sucrets was introduced in Baltimore, Maryland, by Sharp & Dohme in 1932.^[3]

In 1966 the Federal Trade Commission ordered Merck and Company to discontinue the false claims of germ-killing and pain-relieving properties for its Sucrets and Children's Sucrets throat lozenges.^[4] In 1977, it was acquired by Beecham, later merging with SmithKline Beckman in 1989 to form SmithKline Beecham. By 1994 the brand switched from a metal container to a plastic container.^[3] SmithKline Beecham, after announcing a merger with GlaxoWellcome to form GlaxoSmithKline, sold the brand in 2000 to Insight Pharmaceuticals. In 2011, Sucrets reintroduced their product back into the familiar tin due to popular demand and nostalgia.

References

^ Janice Jorgensen (1994). "Sucrets". Encyclopedia of Consumer Brands: Personal products. St. James Press. ISBN 9781558623378. Retrieved 2011-09-24.
^ Gargiulo AV, Burns GM, Huck CP (1992). "Dyclonine hydrochloride--a topical agent for managing pain". Illinois Dental Journal. 61 (4): 303–4. PMID 1286862.
^ ^a ^b "The Sucrets tin joins the age of plastics". USA Today. July 19, 1994. Archived from the original on 2017-08-22. Retrieved 2011-09-24.
^ "F.T.C. Bids Merck Halt Claims That Lozenges Will Kill Germs". The New York Times. Associated Press. April 19, 1966. Retrieved 2011-09-24.