Protein-coding gene in the species Homo sapiens
COX6C |
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Identifiers |
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Aliases | COX6C, cytochrome c oxidase subunit 6C |
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External IDs | OMIM: 124090; HomoloGene: 136781; GeneCards: COX6C; OMA:COX6C - orthologs |
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Gene location (Human) |
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![Chromosome 8 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/6/60/Ideogram_human_chromosome_8.svg/300px-Ideogram_human_chromosome_8.svg.png) | Chr. | Chromosome 8 (human)[1] |
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| Band | 8q22.2 | Start | 99,873,200 bp[1] |
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End | 99,893,707 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - pons
- ventricle
- left ventricle
- body of tongue
- right ventricle
- superior vestibular nucleus
- Skeletal muscle tissue of rectus abdominis
- apex of heart
- biceps brachii
- right auricle
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| | More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/c/c1/PBB_GE_COX6C_201754_at_fs.png/250px-PBB_GE_COX6C_201754_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - cytochrome-c oxidase activity
| Cellular component | - integral component of membrane
- mitochondrial inner membrane
- membrane
- mitochondrion
| Biological process | - proton transmembrane transport
- generation of precursor metabolites and energy
- electron transport chain
- mitochondrial electron transport, cytochrome c to oxygen
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 8: 99.87 – 99.89 Mb | n/a |
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PubMed search | [2] | [3] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.[4][5]
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164919 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 226–7. doi:10.1159/000015185. PMID 10072584.
- ^ a b "Entrez Gene: COX6C cytochrome c oxidase subunit VIc".
External links
Further reading
- Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 61: 309–44. doi:10.1016/S0079-6603(08)60830-2. ISBN 9780125400619. PMID 9752724.
- Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841. S2CID 2286919.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kish SJ, Mastrogiacomo F, Guttman M, et al. (1999). "Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?". J. Neurochem. 72 (2): 700–7. doi:10.1046/j.1471-4159.1999.0720700.x. PMID 9930743. S2CID 32587972.
- Wang FL, Wang Y, Wong WK, et al. (1996). "Two differentially expressed genes in normal human prostate tissue and in carcinoma". Cancer Res. 56 (16): 3634–7. PMID 8705997.
- Otsuka M, Mizuno Y, Yoshida M, et al. (1989). "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc". Nucleic Acids Res. 16 (22): 10916. doi:10.1093/nar/16.22.10916. PMC 338951. PMID 2849755.