Protein-coding gene in the species Homo sapiens
COX6B2 |
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Identifiers |
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Aliases | COX6B2, COXVIB2, CT59, cytochrome c oxidase subunit 6B2 |
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External IDs | OMIM: 618127; MGI: 3044182; HomoloGene: 16948; GeneCards: COX6B2; OMA:COX6B2 - orthologs |
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Gene location (Human) |
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![Chromosome 19 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ideogram_human_chromosome_19.svg/300px-Ideogram_human_chromosome_19.svg.png) | Chr. | Chromosome 19 (human)[1] |
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| Band | 19q13.42 | Start | 55,349,306 bp[1] |
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End | 55,354,719 bp[1] |
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Gene location (Mouse) |
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![Chromosome 7 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png) | Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 A1 | Start | 4,754,791 bp[2] |
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End | 4,756,093 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right testis
- left testis
- buccal mucosa cell
- transverse colon
- mucosa of transverse colon
- testicle
- gonad
- olfactory zone of nasal mucosa
- rectum
- skin of abdomen
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| Top expressed in | - bone marrow
- spermatocyte
- spermatid
- yolk sac
- primary oocyte
- testicle
- secondary oocyte
- embryonic cell
- urinary bladder
- zygote
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - mitochondrial intermembrane space
- mitochondrial crista
- mitochondrion
| Biological process | - proton transmembrane transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001289848 NM_001289849 NM_001289850 NM_183405 NM_183406 |
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RefSeq (protein) | |
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NP_653214 NP_001356727 NP_001356728 NP_001356729 |
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NP_001276777 NP_001276778 NP_001276779 NP_899664 NP_899665 |
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Location (UCSC) | Chr 19: 55.35 – 55.35 Mb | Chr 7: 4.75 – 4.76 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Cytochrome c oxidase subunit VIb polypeptide 2 is a protein that in humans is encoded by the COX6B2 gene. Cytochrome c oxidase 6B2 is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain.[5]
Structure
The COX6B2 gene, located on the q arm of chromosome 19 in position 13.42, contains 5 exons and is 5,113 base pairs in length.[5] The protein encoded by the COX6B2 gene weighs 11 kDa and is composed of 88 amino acids.[6][7] The protein is a subunit of Complex IV, a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.[5]
Function
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane to drive ATP synthesis via protonmotive force. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex.[5]
Summary reaction:
- 4 Fe2+-cytochrome c + 8 H+in + O2 → 4 Fe3+-cytochrome c + 2 H2O + 4 H+out[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000160471 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051811 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c d "Entrez Gene: Cytochrome c oxidase subunit VIb polypeptide 2".
- ^ Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
- ^ "Cytochrome c oxidase subunit VIb polypeptide 2". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 2018-07-19. Retrieved 2018-07-18.
- ^ Voet D, Voet JG, Pratt CW (2013). "Chapter 18". Fundamentals of biochemistry: life at the molecular level (4th ed.). Hoboken, NJ: Wiley. pp. 581–620. ISBN 978-0-470-54784-7.
Further reading
- Taanman JW, Schrage C, Ponne NJ, Das AT, Bolhuis PA, de Vries H, Agsteribbe E (Sep 1990). "Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues". Gene. 93 (2): 285–91. doi:10.1016/0378-1119(90)90237-l. PMID 2172092.
- Hüttemann M, Jaradat S, Grossman LI (Sep 2003). "Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c?". Molecular Reproduction and Development. 66 (1): 8–16. doi:10.1002/mrd.10327. PMID 12874793. S2CID 45002095.
External links
- Human COX6B2 genome location and COX6B2 gene details page in the UCSC Genome Browser.
- Mass spectrometry characterization of COX6B2 at COPaKB[permanent dead link]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.