BCL9L

Protein-coding gene in the species Homo sapiens
BCL9L
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2XB1, 4UP0, 4UP5

Identifiers
AliasesBCL9L, BCL9-2, DLNB11, B-cell CLL/lymphoma 9-like, B-cell CLL/lymphoma 9 like, B cell CLL/lymphoma 9 like, B9L, BCL9 like
External IDsOMIM: 609004; MGI: 1933114; HomoloGene: 65615; GeneCards: BCL9L; OMA:BCL9L - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for BCL9L
Genomic location for BCL9L
Band11q23.3Start118,893,875 bp[1]
End118,925,926 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for BCL9L
Genomic location for BCL9L
Band9|9 A5.2Start44,394,122 bp[2]
End44,423,193 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • right coronary artery

  • stromal cell of endometrium

  • right uterine tube

  • gastric mucosa

  • popliteal artery

  • tibial arteries

  • mucosa of ileum

  • right ovary

  • nipple
Top expressed in
  • basilar part of occipital bone

  • splanchnocranium

  • sphenoid bone

  • thyroid cartilage

  • basisphenoid

  • Meckel's cartilage

  • rib

  • lip

  • hyoid bone

  • Rostral migratory stream
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transcription coactivator activity
  • beta-catenin binding
Cellular component
  • nucleolus
  • nucleus
  • nucleoplasm
  • beta-catenin-TCF complex
Biological process
  • regulation of cell morphogenesis
  • regulation of transcription, DNA-templated
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • positive regulation of epithelial to mesenchymal transition
  • transcription, DNA-templated
  • beta-catenin-TCF complex assembly
  • canonical Wnt signaling pathway
  • somatic stem cell population maintenance
  • skeletal muscle cell differentiation
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

283149

80288

Ensembl

ENSG00000186174

ENSMUSG00000063382

UniProt

Q86UU0

Q67FY2

RefSeq (mRNA)

NM_182557
NM_001378213
NM_001378214

NM_030256
NM_001357490

RefSeq (protein)

NP_872363
NP_001365142
NP_001365143

NP_084532
NP_001344419

Location (UCSC)Chr 11: 118.89 – 118.93 MbChr 9: 44.39 – 44.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

B-cell CLL/lymphoma 9 like is a protein that in humans is encoded by the BCL9L gene. [5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186174 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063382 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: B-cell CLL/lymphoma 9 like". Retrieved 2017-10-31.

Further reading

  • Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W (2006). "Crystal structure of a beta-catenin/BCL9/Tcf4 complex". Mol. Cell. 24 (2): 293–300. doi:10.1016/j.molcel.2006.09.001. PMID 17052462.
  • Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M (2010). "Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor". J. Mol. Biol. 401 (5): 969–84. doi:10.1016/j.jmb.2010.07.007. PMC 2927781. PMID 20637214.
  • Brembeck FH, Wiese M, Zatula N, Grigoryan T, Dai Y, Fritzmann J, Birchmeier W (2011). "BCL9-2 promotes early stages of intestinal tumor progression". Gastroenterology. 141 (4): 1359–70, 1370.e1–3. doi:10.1053/j.gastro.2011.06.039. PMID 21703997.
  • Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T (2011). "Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway". Nat Commun. 2: 548. Bibcode:2011NatCo...2..548M. doi:10.1038/ncomms1551. PMID 22109522.
  • Zatula N, Wiese M, Bunzendahl J, Birchmeier W, Perske C, Bleckmann A, Brembeck FH (2014). "The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis". Oncotarget. 5 (16): 6770–87. doi:10.18632/oncotarget.2252. PMC 4196162. PMID 25149534.
  • El-Hage P, Petitalot A, Monsoro-Burq AH, Maczkowiak F, Driouch K, Formstecher E, Camonis J, Sabbah M, Bièche I, Lidereau R, Lallemand F (2015). "The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells". Mol. Cancer Res. 13 (5): 902–12. doi:10.1158/1541-7786.MCR-14-0180. PMID 25678599.


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