Amine oxidase
An amine oxidase is an enzyme that catalyzes the oxidative cleavage of alkylamines into aldehydes and ammonia:[1]
- RCH2NH2 + H2O + O2 RCHO + NH3 + H2O2
Amine oxidases are divided into two subfamilies based on the cofactor they contain:
| Class | Cofactor | Subclass | Enzyme Commission number | Human genes |
|---|---|---|---|---|
| Amine oxidase (formerly EC 1.4.3.6) | copper | lysyl oxidase | EC 1.4.3.13 | LOX |
| primary-amine oxidase | EC 1.4.3.21 | AOC2, AOC3 | ||
| diamine oxidase | EC 1.4.3.22 | AOC1 | ||
| Monoamine oxidase | flavin | N/A | EC 1.4.3.4 | MAOA, MAOB |
References
- ^ Mondovì B, Finazzi Agrò A (1982). "Structure and Function of Amine Oxidases". Structure and Function Relationships in Biochemical Systems. Advances in Experimental Medicine and Biology. Vol. 148. pp. 141–53. doi:10.1007/978-1-4615-9281-5_12. ISBN 978-1-4615-9283-9. PMID 7124512.
External links
- Amine+Oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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- Glutamate dehydrogenase
- Glutamate synthase (NADPH)
- D-amino acid oxidase
- Amine oxidase (Copper-containing (Lysyl
- Diamine
- Primary-amine)) (Flavin-containing (Monoamine)))
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