Amidohydrolase

Amidohydrolases (or amidases) are a type of hydrolase that acts upon amide bonds.

They are categorized under EC number EC 3.5.1 and 3.5.2.

Examples include:

  • Beta-lactamase
  • Histone deacetylase
  • Urease

The amidohydrolase superfamily is a large protein family of more than 20,000 members with diverse chemistry and physiologic roles. Due to its complexity and size, the amidohydrolase superfamily is being used by the Enzyme Function Initiative (EFI) for developing a large-scale strategy for functional assignment of unknown proteins.[1]

See also

  • iconBiology portal
  1. ^ Gerlt, John A.; Allen, Karen N.; Almo, Steven C.; Armstrong, Richard N.; Babbitt, Patricia C.; Cronan, John E.; Dunaway-Mariano, Debra; Imker, Heidi J.; Jacobson, Matthew P.; Minor, Wladek; Poulter, C. Dale; Raushel, Frank M.; Sali, Andrej; Shoichet, Brian K.; Sweedler, Jonathan V. (2011-11-22). "The Enzyme Function Initiative". Biochemistry. 50 (46): 9950–9962. doi:10.1021/bi201312u. ISSN 0006-2960. PMC 3238057. PMID 21999478.
  • Amidohydrolases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)


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Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
3.5.1: Linear amides /
Amidohydrolases
3.5.2: Cyclic amides/
Amidohydrolases3.5.3: Linear amidines/
Ureohydrolases3.5.4: Cyclic amidines/
Aminohydrolases3.5.5: Nitriles/
Aminohydrolases3.5.99: Other

This EC 3.5 enzyme-related article is a stub. You can help Wikipedia by expanding it.

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