ASXL1 |
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Identifiers |
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Aliases | ASXL1, BOPS, MDS, additional sex combs like 1, transcriptional regulator, ASXL transcriptional regulator 1 |
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External IDs | OMIM: 612990; MGI: 2684063; HomoloGene: 9098; GeneCards: ASXL1; OMA:ASXL1 - orthologs |
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Gene location (Human) |
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![Chromosome 20 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/f/ff/Ideogram_human_chromosome_20.svg/300px-Ideogram_human_chromosome_20.svg.png) | Chr. | Chromosome 20 (human)[1] |
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| Band | 20q11.21 | Start | 32,358,330 bp[1] |
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End | 32,439,319 bp[1] |
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Gene location (Mouse) |
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![Chromosome 2 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 H1 | Start | 153,187,749 bp[2] |
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End | 153,245,927 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - sural nerve
- sperm
- gastric mucosa
- left testis
- ventricular zone
- body of pancreas
- right testis
- oocyte
- epithelium of colon
- left lobe of thyroid gland
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| Top expressed in | - primitive streak
- renal corpuscle
- condyle
- primary oocyte
- medullary collecting duct
- secondary oocyte
- zygote
- fossa
- spermatid
- Rostral migratory stream
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/0/09/PBB_GE_ASXL1_212237_at_fs.png/250px-PBB_GE_ASXL1_212237_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b5/PBB_GE_ASXL1_212234_at_fs.png/250px-PBB_GE_ASXL1_212234_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/6/67/PBB_GE_ASXL1_212238_at_fs.png/250px-PBB_GE_ASXL1_212238_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - DNA binding
- metal ion binding
- protein binding
- peroxisome proliferator activated receptor binding
- transcription coactivator activity
- retinoic acid receptor binding
- chromatin binding
| Cellular component | - PR-DUB complex
- nucleus
- nucleoplasm
| Biological process | - regulation of transcription, DNA-templated
- heart morphogenesis
- monoubiquitinated histone H2A deubiquitination
- transcription, DNA-templated
- lung saccule development
- bone development
- negative regulation of fat cell differentiation
- positive regulation of retinoic acid receptor signaling pathway
- negative regulation of peroxisome proliferator activated receptor signaling pathway
- positive regulation of transcription by RNA polymerase II
- response to retinoic acid
- cell morphogenesis
- animal organ morphogenesis
- protein deubiquitination
- hematopoietic or lymphoid organ development
- thymus development
- bone marrow development
- homeostasis of number of cells
- chromatin organization
- hemopoiesis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001164603 NM_015338 NM_001363734 |
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RefSeq (protein) | |
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NP_001158075 NP_056153 NP_001350663 NP_001158075.1 |
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Location (UCSC) | Chr 20: 32.36 – 32.44 Mb | Chr 2: 153.19 – 153.25 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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